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  • Invasive or Conservative Strategy in Diabetics with ACS?

    atients with diabetes mellitus (DM) are at increased risk of developing acute coronary syndromes (ACS). Furthermore, after hospitalization with ACS, patients with DM are at increased risk of suffering repeat hospitalization for ACS. In recent years, a number of trials have tested the strategy of routine early invasive approach (i.e., diagnostic angiography with a view to revascularization) vs an early conservative strategy (i.e., medical management with coronary angiography only performed in cases of refractory ischemia).
  • Rapid Rule Out for Patients with Chest Pain

    Chest pain presentations to the emergency department (ED) are common and very costly to the health care system. Although the event rates are low in patients with a low clinical risk profile, the price of a missed diagnosis is high. Some low-risk patients who are discharged from the ED may suffer a myocardial infarction (MI) and potentially even die.
  • Pharmacology Watch: FDA Approves First New Anti-Obesity Drug in Years

    Lorcaserin for weight loss; statins and fatigue; treatment-resistant gonorrhea; hydrocodone classification changes; USPSTF recommendations; and FDA actions.
  • Survival After Out-of-Hospital Cardiac Arrest

    In this paper, the authors reviewed long-term survival data from a large population of out-of-hospital cardiac arrest patients who were discharged alive after their arrest. All patients who have a cardiac arrest in Seattle and King County, Washington, are entered into a registry organized to follow the Utstein guidelines for reporting cardiac arrest.
  • Cardiac Resynchronization Therapy: Who Responds?

    This study examines the patterns of response to cardiac resynchronization therapy (CRT) among patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial.
  • Pharmacology Watch

    Drug shortages; metformin and cancer prevention; migraine prevention guidelines; and FDA actions.
  • Clinical Briefs in Primary Care Supplement

  • Oral Anticoagulants During Pregnancy

    Newer bileaflet mechanical heart valves require lower doses of oral anticoagulants to avoid valve thrombosis and embolism genesis. However, little is known about the safety of low-dose regimens in pregnant women who have a hypercoagulable state, yet warfarin embryopathy is known to be dose related.
  • Perioperative Risk in Patients with Coronary Stents

    It is well known that the risk of perioperative major adverse cardiac events (MACE) is high in patients with coronary stents, especially early after stent implantation.
  • Riata ICD Lead Failures

    The Riata and Riata ST ICD leads manufactured by St. Jude Medical have recently come under increased scrutiny because of the observation that the conductor cables could extrude from the outer insulation.