Articles Tagged With: brain
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Epigenetic Changes in Perilesional Brain Tissue After Radiotherapy
Epigenetic and transcriptomic studies of irradiated perilesional brain tissue identified clear changes in deoxyribonucleic acid (DNA) methylation patterns and neuropeptide upregulation that contributed to neuroinflammation, which may underly radiation-related neurotoxicity.
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Researchers Face Many Ethical Challenges with HEALthy Brain and Child Development Study
The HEALthy Brain and Child Development study is looking at the effect of various prenatal and postnatal exposures on pediatric brain and behavioral development. To answer important questions about early life influences on developmental trajectories, researchers are recruiting a large cohort of pregnant individuals. Some participants have substance use disorders.
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Ethical Debate Over Normothermic Regional Perfusion
Medical Ethics Advisor interviewed Adam Omelianchuk, PhD, an assistant professor at Baylor College of Medicine’s Center for Medical Ethics and Health Policy and lead author of a paper on ethical concerns involving normothermic regional perfusion.
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Is Brain Impairment Following COVID-19 Hospitalization Worse Than for Other Severe Illnesses?
The authors of this prospective cohort study with matched controls found that long-term brain health following severe COVID-19 hospitalization was impaired but was similar to hospitalization from other severe diseases.
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Lack of Brain Temperature Variation May Predict Mortality Among Patients with Brain Injury
Variations in brain temperature appear to be a normal physiological variable. An absence of brain temperature variation may be a novel predictor of mortality among patients with brain injury.
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Inflammatory Foods Could Accelerate Brain Aging
In the Framingham Offspring cohort of subjects, those with a higher index of inflammatory foods recorded smaller brain volume, less grey matter.
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Neurologists Look Beyond Traditional Addiction Treatment Techniques
Researchers explore why some patients were suddenly no longer craving nicotine after the appearance of a brain lesion.
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Your Brain on COVID: Damage Found in Two New Studies
Dementia and other adverse effects on the brain are occurring in some COVID-19 survivors, an ominous finding for the millions infected — even those with only mild symptoms, according to two new studies.
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Neuropathological Variability of NMDAR-Encephalitis
The neuropathological features of N-methyl-D-aspartate receptor (NMDAR)-encephalitis are described in an autopsy cohort of four patients — two diagnosed in life with comorbid brain disorders, and two diagnosed at autopsy and never treated. The two untreated patients had inflammatory infiltrates composed of perivascular and parenchymal T cells and B cells/plasma cells in the basal ganglia, amygdala, and hippocampus. The two treated patients had variable pathologies that reflected their underlying neurological disorders (lymphoproliferative disease and multiple sclerosis). Overall, the topographic distribution of inflammation in patients with NMDAR-encephalitis reflects the clinical symptoms of movement disorders, abnormal behavior, and memory dysfunction with inflammation predominantly observed in the basal ganglia, amygdala, and hippocampus. Loss of NMDAR-immunoreactivity correlated with disease severity.
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Neuropathological Findings in the Brains of Patients Who Died from COVID-19
In an autopsy study of 41 patients who died from COVID-19 in a single medical center in New York City, most of the brain pathology was the result of hypoxic-ischemic injury, infarction, and hemorrhage, with microglial activation and neuronophagia caused by inflammation. Studies for the presence of viral proteins were negative, and very low levels of viral ribonucleic acid were detected.