Articles Tagged With: brain
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IRBs Facing Ethically Controversial Questions on Brain Research
The field of brain research sounds a lot like science fiction, but human neural organoids, human neural transplants, and human-animal chimeras all are imminent realities. IRBs are going to be facing some difficult decisions on whether this research can proceed. The authors of a recent report examined these issues.
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Localized Slow Wave Sleep in the Awake but Inattentive Brain
Electroencephalogram studies of humans during periods of “mind wandering” and “mind blanking” have shown regional changes that suggest parts of the brain may be asleep while other areas are activated.
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Dietary Modifications with Linoleic Acid Can Have an Effect on Gut and Brain Inflammation
This study evaluated the use of dietary conjugated linoleic acid (CLA) supplementation to modulate the disease outcome in a spontaneous mouse model of central nervous system autoimmunity and also studied patients with relapsing-remitting multiple sclerosis receiving CLA supplementation. CLA may act as a modulator of the gut-brain axis by targeting immune cells in the gut, with a subsequent effect in the brain.
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Nocardia Brain Abscess
A review of 24 cases of Nocardia brain abscess, two-fifths of which occurred in apparently non-immunocompromised hosts, had variable outcomes, but antibiotic therapy was effective in most. -
Brain Cancer and Brain Injury Drive Systemic Immunosuppression
Glioblastoma-associated immunosuppression is a significant factor associated with poor survival in this disease. Accumulating evidence suggests that mouse models of glioblastoma and other brain cancers induce systemic immunosuppression through dysregulation of a newly recognized brain-thymus axis and that targeting this pathway may promote more effective immune surveillance of these tumors.
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Phospho-Tau217 Blood Biomarker May Help to Diagnose Early Alzheimer’s Disease
Serum phospho-tau217, a biomarker of tau protein that can be detected in the blood, is increased in preclinical Alzheimer’s disease and may have clinical utility for the early detection of brain pathology.
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The Need for More Post-Acute COVID-19 Care Is on the Rise
Hospitals nationwide have focused on handling overflow of COVID-19 patients needing acute care. They also are developing programs to handle post-acute medical problems discharged COVID-19 patients face.
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Deficits in Neurotransmitters and Behavioral Disturbances in Frontotemporal Lobar Degeneration
In subjects with a syndrome associated with frontotemporal lobar degeneration, gamma aminobutyric acid and glutamate deficiency in the right inferior frontal gyrus was associated with greater degrees of impulsivity.
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Hospital to Stand Trial for Botched Brain Surgery Performed with Recalled Laser
As often is the case in medical malpractice cases, defendants made a concerted effort to dismiss the case based on the insufficiency of the plaintiff’s expert report. Here, however, the court of appeals began its analysis by specifying that based on the applicable standard of review, the purpose of the plaintiffs’ expert report is to demonstrate the plaintiff is not filing a frivolous lawsuit.
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Multiple Sclerosis and Vascular Disease
Researchers evaluated the presence and pathological significance of extracranial systemic and cerebral small vessel disease in patients with multiple sclerosis (MS) compared to healthy controls. MS patients exhibited less systemic vascular disease and more small vessel disease in the brain vs. controls.