Articles Tagged With: antibiotics
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Antibiotic Cycling Is Not Useful for Reducing Antibiotic-resistant Gram-negative Pathogens in Patients Admitted to Intensive Care Units
A randomized study that included eight intensive care units in Europe found no reduction in mortality or carriage of antibiotic-resistant gram-negative pathogens with antibiotic cycling compared to antibiotic mixing.
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What Effect Do Antibiotics Have on Hormonal Contraception?
Data do not support drug interactions between hormonal contraceptives and non-rifamycin antibiotics.
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Prolonged vs. Short Duration Infusion of Beta-lactam Antibiotics: The Verdict Is In
When compared to shorter infusion duration, prolonged infusion of anti-pseudomonal β-lactam antibiotics was associated with reduced mortality.
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Which Antibiotics Are Safe in the First Trimester of Pregnancy?
A total of 7.2% of pregnant women were diagnosed with a urinary tract infection, and of these, 69% filled an antibiotic prescription. The most common antibiotics prescribed in the first trimester were nitrofurantoin, ciprofloxacin, cephalexin, and trimethoprim-sulfamethoxazole.
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Stewardship, Science, and Spirituality
Awareness of a patient’s and family’s belief system might help physicians appropriately frame explanations about the importance of antimicrobial stewardship.
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Antibiotics and Adverse Events: Doctors, Do No Harm
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 (20%) experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 (19%) of the antibiotic regimens were not clinically indicated, and 56 (20%) of these were associated with an adverse drug event.
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Do Antibiotics Reduce Hormonal Contraceptive Effectiveness?
This is a systematic review of studies evaluating the effect of concomitant non-rifamycin antibiotic use on hormonal contraceptive effectiveness. Although data are limited, there is no evidence to support the existence of drug interactions.
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Microbiology of Hidradenitis Suppurativa: New Evidence That Anaerobes Predominate
Using metagenomic techniques, investigators determined that two Gram-negative anaerobes, Prevotella and Porphyromonas, predominate in hidradenitis suppurativa lesions. Two others, Fusobacterium and Parvimonas, correlate with disease severity.
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Skin and Soft Tissue Infections
Skin and soft tissue infections are encountered commonly in the emergency department, presenting as a range of disorders, from uncomplicated cellulitis, impetigo, folliculitis, erysipelas, and focal abscesses to necrotizing fasciitis.
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Dual Antibiotic Therapy Is Not Routinely Necessary for Uncomplicated Cellulitis
A randomized, multicenter, placebo-controlled clinical trial that enrolled patients presenting to emergency departments with uncomplicated cellulitis found the addition of trimethoprim-sulfamethoxazole to cephalexin did not lead to better outcomes.