Articles Tagged With:
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Long-Term Outcomes of Peripartum Cardiomyopathy
A large, prospective, observational study from Israel of peripartum cardiomyopathy has shown that, in general, outcomes are favorable, with high rates of left ventricular function recovery that remain stable and with no mortality but also that show high rates of cardiovascular comorbidities during long-term follow-up.
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Fertility-Sparing vs. Surgical Treatment for Stage I Endometrial Cancer
This retrospective cohort study using the National Cancer Database demonstrated similar overall survival between fertility-sparing treatment and hysterectomy for patients younger than 40 years of age with clinical stage 1, low-grade endometrial cancer (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.50-2.00) but an increased mortality risk for patients aged 40-49 years receiving fertility-sparing treatment (HR, 4.94; 95% CI, 1.89-12.91).
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Spironolactone for the Treatment of Acne Vulgaris
In this meta-analysis of 563 patients from five randomized controlled trials, objective assessment of acne improvement was higher in the spironolactone group compared to the placebo group (odds ratio, 6.59; 95% confidence interval, 3.50-12.43).
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Acetaminophen Use During Pregnancy and Neurodevelopmental Disorders
The synthesized evidence on prenatal acetaminophen exposure and neurodevelopmental outcomes highlights modest and inconsistent associations and emphasizes that causality remains unproven because of confounding and measurement biases. The authors conclude that, consistent with American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine guidance, acetaminophen remains appropriate in pregnancy when clinically indicated.
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Long-Term Outcomes of Peripartum Cardiomyopathy
A large, prospective, observational study from Israel of peripartum cardiomyopathy has shown that, in general, outcomes are favorable, with high rates of left ventricular function recovery that remain stable and with no mortality but also that show high rates of cardiovascular comorbidities during long-term follow-up.
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Early vs. Late Catheter Ablation for Atrial Fibrillation in Older Patients
An observational study from China in older patients with persistent atrial fibrillation (AF) has shown that an earlier diagnosis to catheter ablation time of ≤ 12 months compared to > 12 months is associated with lower rates of AF recurrence and adverse cardiovascular outcomes.
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Ablation vs. Drugs for Ventricular Tachycardia
A sub-analysis of the VANISH2 trial, which compared catheter ablation (CA) to antiarrhythmic drug therapy for the suppression of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy has shown that in the sotalol therapy group, those randomized to CA less frequently experienced the VT-based composite endpoint. Conversely, in the amiodarone group, the primary endpoint was similar in the CA- and drug therapy-randomized patients, but amiodarone produced more adverse events.
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Improved Major Arrhythmic Event Prediction in Non-Ischemic Cardiomyopathy
An international multicenter registry study of patients with non-ischemic cardiomyopathy without a history of major arrhythmic adverse cardiac events (MAACE) that compared a new cardiac magnetic resonance imaging score for predicting MAACE and consequently determining the need for a primary prevention implantable cardioverter defibrillator has found that this new score is superior to the standard left ventricular ejection fraction criterion.
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Novel Drug-Coated Balloon Compares Favorably to DES in De Novo Disease and ISR
In two related largest-to-date clinical trials, a sirolimus-eluting balloon was noninferior to current-generation drug-eluting stents (DES) in both de novo lesions and in-stent restenosis (ISR).
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Opioid Use Disorder in the ED: A Case-Based Approach
The emergency department (ED) is a critical touchpoint for identifying, initiating, and linking patients with opioid use disorder (OUD) to ongoing care.