Articles Tagged With: Sepsis
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Procalcitonin-Guided Care Leads to Shorter Duration of Antibiotics in Sepsis
In this multicenter, intervention-concealed, randomized clinical trial of 2,760 critically ill patients hospitalized with sepsis, the use of a daily procalcitonin-guided protocol resulted in shorter antibiotic duration as compared with standard care, without a significant difference in 28-day all-cause mortality. There was no significant difference in antibiotic duration between patients managed with a daily C-reactive protein-guided protocol and standard care, and the difference in all-cause mortality between these two groups was inconclusive.
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Procalcitonin-Guided Care Leads to Shorter Duration of Antibiotics in Sepsis Patients
In this multicenter, intervention-concealed, randomized clinical trial of 2,760 critically ill patients hospitalized with sepsis, the use of a daily procalcitonin-guided protocol resulted in shorter antibiotic duration as compared with standard care, without a significant difference in 28-day all-cause mortality. There was no significant difference in antibiotic duration between patients managed with a daily C-reactive protein-guided protocol and standard care, and the difference in all-cause mortality between these two groups was inconclusive.
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Mortality in Sepsis Patients Treated with Piperacillin-Tazobactam vs. Cefepime
A retrospective cohort study that included more than 7,000 patients with sepsis and no clear indication for anti-anaerobic coverage found receipt of piperacillin-tazobactam was associated with higher mortality and increased duration of organ dysfunction compared to cefepime.
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Another Step in the Journey to Combat Diagnostic Errors in Hospitalized Patients
Diagnostic errors in hospitalized patients who died or were transferred to the intensive care unit were common in this large retrospective, multicenter trial and frequently associated with patient harm. Problems with clinical assessment and ordering and interpreting tests were the most prevalent diagnostic process faults, with sepsis the diagnosis most associated with diagnostic error.
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ED Malpractice Claims Alleging Missed Sepsis Include These Allegations
Plaintiffs’ attorneys are increasingly scrutinizing ED care for failure to promptly identify and treat sepsis.
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Lack of Data Is a Challenge for ED Sepsis AI Tools
When a patient first arrives at an ED, there usually is not much hard data available. This makes it very challenging for triage nurses to determine if sepsis is a possibility.
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Does AI-Driven Tool Improve Evidence-Based Care and Reduce Sepsis Mortality?
New data show that an artificial intelligence-driven tool, deployed in UC San Diego Health emergency departments, can not only pick up on the subtle signs of sepsis at an early stage, but the data also strongly suggest that use of the tool can significantly reduce mortality.
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Pediatric Sepsis Criteria Focus on Organ Dysfunction Indicators
The new criteria mark the first update to pediatric sepsis criteria in nearly two decades.
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Does Alkaline Phosphatase Reduce Sepsis-Associated Acute Kidney Injury?
This Phase III, international, multicenter, double-blind, randomized controlled trial did not show a reduction in 28-day all-cause mortality with ilofotase alfa (recombinant human alkaline phosphatase). However, the study showed evidence to suggest that ilofotase alfa reduced major adverse kidney events at 90 days, mainly driven by lowering the incidence of renal replacement therapy through day 90 in these patients.
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A Partial List of 2023 Lawsuits on Abortion and Reproductive Rights
Reproductive rights attorneys were busy in 2023 and are continuing the legal fight in 2024.