Articles Tagged With: Biomarkers
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Clinical Consequences of Alzheimer’s and Lewy Body Co-Pathologies
This large study of patients with cognitive impairment-assessed cerebrospinal fluid biomarkers, positron emission tomography imaging, and cognitive tests showed that those with evidence of both Alzheimer’s and Lewy body pathologies had greater cognitive dysfunction and faster progression than those with either pathology alone.
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Blood Biomarkers for the Diagnosis of Alzheimer’s Disease
In this population-based study of patients in Sweden with cognitive complaints, mild cognitive impairment, and dementia, the use of blood biomarkers, specifically, phosphorylated tau 217 and amyloid-beta 42/40 ratios, improved the diagnostic accuracy for pathological Alzheimer’s disease in primary care patients as well as patients seen by dementia specialists.
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Timing of Biomarker Changes in Alzheimer’s Disease
In a longitudinal multicenter, nested case-control study of cognitive normal participants from China, the time courses of key Alzheimer’s disease biomarkers were identified during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease.
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Cumulative Number of Head Strikes Contributes to the Development of CTE
A recent study evaluated the connection between head impact and chronic traumatic encephalopathy (CTE) in male athletes and found that the total number and severity of head impacts throughout life better predicted CTE than the number of symptomatic concussions.
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Biomarker Profiles of Those Living to Age 100 Years
Among 1,224 participants who lived to their 100th birthday, there were higher levels of total cholesterol and iron, and lower levels of glucose, creatinine, uric acid, liver enzymes, and alkaline phosphatase compared with non-centenarians. These differences were seen as early as age 65 years.
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Can a Blood-Based Test Serve as a Biomarker for Parkinson’s Disease?
The authors of this proof-of-concept study proposed that a noninvasive assay detecting pathology-associated α-synuclein extracted from blood may reveal a reliable biomarker for Parkinson’s disease.
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Using Biomarkers to Predict Traumatic Brain Injury Outcomes
Measuring proteins on day of injury could help improve current predictive models.
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Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers.
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Use of Serum Biomarkers in Determining Prognosis After Cardiac Arrest
Used in conjunction with the clinical exam and brain imaging, serum biomarkers, such as neurofilament light, can help refine the prognostication for patients who have experienced severe anoxic/ischemic brain injury after cardiac arrest.
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Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers; however, the various neurodegeneration biomarkers were not equivalent and should not be used interchangeably.