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Evaluation of non-Parkinsonian carriers of the LRRK2 mutation associated with Parkinson's disease supports a model of pre-motor symptomatology, including impaired color discrimination and constipation, that could be related to pathology developing prior to that in the substantia nigra.
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Symptoms of muscle pain and discomfort are common with statin use, but weakness and creatine kinase elevation are unusual.
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Gabapentin enacarbil is effective for sleep disturbance in moderate-to-severe primary restless legs syndrome, but frequently causes sleepiness and dizzinesss.
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Abdominal pain with vomiting is a common presenting complaint to the emergency department (ED) in infants. In the majority of cases, the patient's symptoms come from a benign cause such as gastroenteritis. However, it remains essential for the emergency physician (EP) to thoroughly understand the differential diagnosis of abdominal pain and vomiting in infants, particularly identifying those causes requiring surgical intervention.
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Pulmonary contusions are a frequent complication of chest trauma and may have serious morbidity and mortality associated with them. Early recognition, aggressive management, and a targeted diagnostic approach may optimize outcomes for these patients. The authors present a concise, comprehensive review of the current status of identification and management of pulmonary contusions.
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