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An oral multikinase inhibitor has been approved by the FDA for treatment of metastatic colorectal cancer as well as advanced gastrointestinal stromal tumors (GIST). Regorafenib is marketed by Bayer HealthCare Pharmaceuticals as Stivarga.
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Special Subgroups in Hypertension: Obese Hypertensives; Selection Criteria for Lung Cancer Screening; Extended Treatment of VTE with Dabigatran vs Warfarin
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Identifying and managing agitated pediatric patients in the emergency department (ED) can be stressful and challenging for patients, families, and providers.
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AIDS- and HIV-related infections have changed significantly over the last decade. Although the overall incidence has declined, young adults have shown an increase in AIDS, with 50% of all new HIV infections in this age group. Many of these new HIV infections are in patients who are late presenters. These patients have received less care and are more likely to have unknowingly transmitted the infection. Routine screening identifies patients earlier, decreases the stigma associated with HIV testing, and increases the likelihood of future testing during risky behavior periods. The authors review the current role of the ED provider in identifying and managing patients with potential HIV.
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Borderline personality disorder (BPD) is a striking personality dysfunction characterized by inherent difficulties with self-regulation as well as chronic self-destructive behavior. In patients with this disorder, the pain experience is seemingly paradoxical. During acute self-destructive acts, up to 80% of individuals with BPD describe attenuated responses to pain (i.e., high tolerance of pain).
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Results of a current study of women using the contraceptive injection depot medroxyprogesterone acetate (DMPA, Depo-Provera, Pfizer, New York City; Medroxyprogesterone Acetate Injectable Suspension USP, Teva Pharmaceuticals USA, North Wales, PA) indicate a modest increase in fracture risk compared with women using other contraceptive methods; however, the increased risk of fracture preceded the start of method use, analysis shows.
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A new campaign launched Valentines Day 2013 is stressing the importance of preconception health for every young woman, not just those who are planning a pregnancy.
