Primary Care/Hospitalist
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Blood Pressure Targets in the Elderly
The authors of a large population study found that reducing blood pressure to < 140/90 mmHg is associated with increased mortality, and mortality was highest in those with previous cardiovascular events and age > 80 years.
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Vaping and Severe Acute Pneumonitis
Hundreds of cases of lung injury possibly related to vaping have been reported to the CDC. Evidence to date suggests the illness is a form of acute lipoid pneumonia likely related to inhalation of lipid materials.
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What Might Account for the ST-T Changes?
The ECG in the figure was obtained from a 65-year-old woman who presented with an exacerbation of heart failure. A medical history revealed she was taking multiple medications. The patient was dyspneic and complained about intermittent chest pain.
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Pitolisant Tablets (Wakix)
Pitolisant should be prescribed to treat excessive daytime sleepiness in adult patients with narcolepsy.
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When Did You Last Take an Antibiotic?
Approximately half of U.S. residents with health insurance filled an antibiotic prescription over a two-year period.
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Risk of Neuropathy With Fluoroquinolones
As a class, fluoroquinolones are some of the most commonly used antibiotics worldwide. Their use carries a significant risk of neurotoxicity, for both the peripheral and central nervous system.
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Neuropathy After Total Knee Arthroplasty
In a large series of cases from the Mayo Clinic, 54 cases of new neuropathy occurred in 14,450 total knee arthroplasties. Most were isolated peroneal neuropathies. No specific risk factors were identified.
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NOACs vs. Warfarin: What Are the Data in Patients With Traumatic Brain Injury and Intracranial Hemorrhage?
A three-year analysis of a prospectively maintained database with traumatic brain injury patients revealed that novel oral anticoagulant use is associated with increased risk of intracranial hemorrhage progression, neurosurgical intervention, and mortality.
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Mental Health Conditions May Be Linked to Unnecessary Oophorectomies
Results from a new study identify mental health conditions associated with an increased risk of unnecessary bilateral oophorectomies, despite nonmalignant indications. Related research indicates that hysterectomy is associated with an increased risk of long-term mental health issues, including depression and anxiety.
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Early Clinical Trial Data Suggest Potential Chlamydia Vaccine Safe for Use
Results of an early trial of a potential chlamydia vaccine indicate it is safe for use. While the vaccine, the first to reach Phase 1 clinical trial status, demonstrates promising early signs, further studies are needed to determine whether the immune response fully protects against chlamydia infection.