Primary Care/Hospitalist
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Daridorexant Tablets (Quviviq)
Daridorexant can be prescribed to adult patients with insomnia characterized by difficulty with sleep onset and/or sleep maintenance.
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Delaying Antibiotics in Patients with Suspected Infection Increases Risk of Septic Shock
A retrospective cohort study revealed delaying the first dose of antibiotics in patients suspected of presenting with an infection in the ED led to a higher risk of progressing to septic shock and in-hospital mortality. Every hour antibiotics were delayed raised the risk of septic shock by 4%.
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How Certain is a Negative Echocardiogram for Excluding Infective Endocarditis?
Applying the proposed strict negative criteria for infective endocarditis (IE) on the first echocardiogram indicated this approach largely prevented unnecessary repeat tests unless clinically indicated for continued suspicion of IE.
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Yoga for the Mind, Body, and Autonomic Nervous System
Randomization to yoga in addition to standard care to treat vasovagal syncope led to better outcomes than standard care alone, with reductions in syncopal and presyncopal events and improvement in quality of life scores at one year.
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Finding the Most Effective Treatment for Hair Loss in Men
Among three common treatments for male androgenic alopecia, the authors of a meta-analysis found 0.5 mg/day of dutasteride to be the most effective.
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Prevalence of Acute Myocarditis Related to COVID-19 Vaccination and SARS-CoV-2
Acute myocarditis is a diagnosis that has had a significant rise in prevalence and is the center of many recent discussions in the medical literature. Much of this recent increase has been secondary to SARS-CoV-2 and the COVID-19 vaccines. Amid the global SARS-CoV-2 pandemic, acute myocarditis has become much more prevalent in patients where it was previously a rare pathology. As a result of this outbreak, it has become a disease entity necessitating new and ever evolving clinical guidelines.
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Bebtelovimab Injection
The FDA has issued an emergency use authorization for a monoclonal antibody that demonstrated efficacy against the omicron variant of COVID-19.
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VIRSTA vs. PREDICT: Which Is Best for Anticipating Endocarditis?
Researchers in Columbia put predictive scoring methods through their paces.
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Importance of Exercise Testing-Associated Ventricular Ectopy
A study of asymptomatic subjects without known cardiovascular disease undergoing treadmill exercise testing and followed for a mean of 20 years showed high-grade premature ventricular contractions during exercise recovery (but not during exercise) are predictive of subsequent cardiovascular mortality.
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Herpes Simplex Virus 2 Meningitis in Adults
The incidence of herpes simplex virus 2 meningitis in adults in Denmark over a six-year period was 0.7/100,000 population per year, with 91% of cases occurring in the absence of immunocompromise.