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The FDA has approved a new drug with a novel mechanism of action for the treatment of rheumatoid arthritis in patients intolerant to or who have had inadequate response to methotrexate. Tofacifinib is an oral Janus kinase (JAK) inhibitor and is marketed by Pfizer as Xeljanz.
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A randomized, controlled trial showed that moderate doses of simvastatin or pravastatin resulted in reduced energy or exertional fatigue in up to 40% of patients, especially in women.
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This study does not support the hypothesis that high calcium intake increases coronary artery calcification
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Sedentary time is associated with an increased risk of diabetes, cardiovascular disease, and cardiovascular and all-cause mortality.
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Zoledronic Acid Treatment of Osteoporosis in Men; Relapsing Lyme Disease: Fact or Fiction?; Hypertension and Gout
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In a prospective cohort of obese, reproductive-aged women, there were no changes in the number of ovulatory cycles, but there was a shortening of the follicular phase and an improvement in sexual function after gastric bypass surgery.
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OB/GYN Clinical Alert editorial board transitions.
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Overt maternal hypothyroidism and hyperthyroidism each complicate about 3/1000 pregnancies. However, subclinical hypothyroidism can accompany as many as 2.5% of pregnancies. Both problems require careful surveillance because of the potential to cause significant maternal and fetal complications.
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