Browse Obstetrics/Gynecology General Articles by Topic

The Proton Pump Inhibitor Use and Hypertension Link in Menopausal Women

In a large study, long-term use of proton pump inhibitors in menopausal women was associated with an increased risk of developing hypertension.

Comparison of the Mini and Standard Copper IUD

This Phase III randomized clinical trial demonstrated a three-year cumulative pregnancy rate of 4.8% (95% confidence interval, 2.75 to 6.86) for the NTCu380 mini intrauterine device (IUD), with similar discontinuation rates between the mini copper IUD and the TCu380A standard copper IUD (51.3% vs. 57.3%, P = 0.07), but fewer discontinuations for bleeding and pain for the mini copper IUD (14.5% vs. 27.3%, P < 0.001).

Antenatal Corticosteroids for the Periviable Fetus at 22 Weeks of Gestation

The 2021 American College of Obstetricians and Gynecologists/Society for Maternal-Fetal Medicine practice advisory significantly increased the use of antenatal corticosteroids at 22 weeks of gestation in U.S. hospitals planning neonatal resuscitation, highlighting both the powerful influence of clinical guidelines on practice patterns and the persistence of disparities driven by sociodemographic factors.

What Is the Risk of CT Exposure Before Conception?

In this retrospective cohort study among 5,142,339 pregnancies in Ontario, Canada, exposure to preconception computed tomography (CT) was weakly associated with spontaneous pregnancy loss (adjusted hazard ratio [aHR], 1.08; 95% confidence interval [CI], 1.07 to 1.08 for one CT scan; aHR, 1.14; 95% CI, 1.12 to 1.16 for two CT scans; and aHR, 1.19; 95% CI, 1.16 to 1.21 for three or more CT scans). For the 3,451,968 live births, there was a similar weak association with congenital anomalies (aHR, 1.06; 95% CI, 1.05 to 1.08 for one CT scan; aHR, 1.11; 95% CI, 1.09 to 1.14 for two CT scans; and aHR, 1.15; 95% CI, 1.11 to 1.18 for three or more CT scans).

Cancer Survivors and Patients Need Individualized Contraceptive Counseling

Clinicians increasingly are gearing their contraceptive counseling to the specific needs and desires of each patient. Cancer patients and survivors need person-centered contraceptive counseling that is geared toward their bodies and circumstances.

Identifying Potential Missed Opportunities to Prevent Ovarian Cancer

A new study found that nearly one in four ovarian cancer patients with high-grade serous cancer (HGSC) could have been offered bilateral salpingectomy at the time of a prior abdominal surgery, potentially preventing their cancer diagnosis.

Managing Suspected Preeclampsia Using the sFlt-1/PlGF Ratio

The sFlt-1/PlGF ratio is a clinically valuable tool for ruling out preeclampsia and improving obstetric decision-making, although its effect depends on appropriate use, clinician confidence in negative results, and adherence to validated protocols.

Endometrial Biopsy: What Leads to an Insufficient Sample?

In this large retrospective cohort study at a single health system, the rate of insufficient endometrial biopsies among 27,456 patients was 12.1%. The largest risk factor for an insufficient sample was postmenopausal status (adjusted odds ratio, 5.27; 95% confidence interval, 4.88-5.70). Among premenopausal women, a history of cesarean delivery (9.6% vs. 7.2%; P < 0.001) and leiomyomas (10.3% vs. 7.2%; P < 0.001) was associated with insufficient samples.

Is Routine Voiding Necessary Following Minimally Invasive Hysterectomy?

This unblinded, randomized clinical trial of patients undergoing minimally invasive benign nonurogynecologic hysterectomy with anticipated same-day discharge demonstrated that eliminating the requirement to void prior to discharge reduced time spent in the post-anesthesia care unit by 27.14 minutes (173.26 mins no void vs. 201.95 mins void; P = 0.002) without increasing the proportion of patients with postoperative urinary retention (3% void vs. 1% no void; P = 3.69).

A Closer Look at a New Low-Dose Copper IUD

This study reports on the three-year data from an ongoing Phase III study evaluating the efficacy, safety, and tolerability of a new low-dose copper intrauterine device (IUD), demonstrating low rates of expulsion and discontinuation and expanding the nonhormonal IUD options available in the United States.