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In this issue: Rivaroxaban may be dabigatran's first competitor; a new way to measure non-adherence to medication therapy; FDA Actions.
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The rate of sepsis with group b streptococcus (gbs) in neonates of colonized mothers is now less than 1%.
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The authors randomized women with objectively validated heavy menstrual bleeding (mean menstrual blood loss [MBL] of 80 mL or more per cycle, confirmed using the alkaline hematin methodology during two pretreatment cycles) to treatment with oral tranexamic acid 3.9 g/d or placebo for up to 5 days per cycle for 6 menstrual cycles.
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Nearly every reference source discussing the primary management of advanced ovarian cancer will highlight the role of surgical cytoreduction as an important first step in the care of this disease.
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This trial was a randomized double-blind control trial of 89 women undergoing consecutive removal and replacement of a levonorgestrel-releasing intrauterine device (LNG-IUD). Of note, this study was part of a larger multicenter trial evaluating the bleeding profile and safety with repeat use of a LNG-IUD in women who had used their first device for close to 5 years.
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Early Detection and Treatment of Ovarian Cancer Improves Outcome: Right?
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The authors investigated invasive breast cancer incidence and mortality after a total follow-up of 11 years among the 16,608 postmenopausal women aged 50-79 years with no prior hysterectomy who were randomized to combined oral conjugated equine estrogens (0.625 mg/day) plus medroxyprogesterone acetate (2.5 mg/day) or placebo in the Women's Health Initiative (WHI) HRT study. In the initial reports from the WHI HRT study, breast cancer incidence was increased (hazard rate [HR], 1.26; 95% confidence interval [CI], 1.00-1.59).
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For many years we have been pushing the concept that the earlier that prenatal care is initiated, the better will be the outcome. Since there are certainly data proving that late enrollment makes for worse outcomes, this "the-earlier-the-better" mantra has almost attained bumper sticker status.
