To determine the risk of potentially unintended discontinuation of common, evidence-based medications for chronic disease, Bell and colleagues examined administrative records for 12 years (19972009) for all hospitalized patients and all outpatient prescriptions in Ontario, Canada.
This was a prospective, randomized, controlled, multicenter trial that took place between 2007 and 2010 at seven ICUs in Belgium. Inclusion criteria were evidence of nutritional impairment or significant risk for it (measured using a validated and standardized nutritional risk screen questionnaire) and age > 18 years.
Saddle pulmonary embolism (SPE) is defined as the presence of a thromboembolus located at the bifurcation of the main pulmonary artery.
In this issue: Medication poisonings in children; rosuvastatin vs atorvastatin for atherosclerosis; saw palmetto for prostate symptoms; using atypical antipsychotics for off-label indications in adults; and FDA actions.
Measurement of biomarkers, including Ab42 and tau protein in the CSF along with volumetric measurements of the hippocampus, may help in the diagnosis of early or presymptomatic Alzheimer's disease.
