Sickle cell disease celebrated its 100th anniversary last year, prompting consideration of what has transpired for those with the disease since its description by Dr. James Herrick in 1910.
This paper presents the findings from a systematic review and meta-analysis of available randomized, controlled trials (RCTs) published through July 2011 and retrieved from a variety of electronic search databases worldwide.
When I was a medicine resident 40 years ago just as the first ICUs were being introduced, treatment for life-threatening bacterial infections consisted of antibiotics, control or removal of the primary source, intravenous fluids, and vasopressors.
