Browse Neurology Articles by Topic

The Best Rate Control Agent for Sepsis and Atrial Fibrillation

Sepsis and atrial fibrillation are common in the ICU, and the presence of both together is not a rare occurrence. Here's how to handle them.

Leigh Syndrome: Insights and Implications from Advances in Next-generation Sequencing

Leigh syndrome is a genetically heterogeneous neurodevelopmental disorder. The application of next-generation sequencing has enabled a deeper understanding of the diverse nature of the genetic and molecular etiologies that give rise to the shared clinical phenotype of Leigh syndrome.

Differentiating Sarcoidosis from Neuromyelitis Optic in Patients with Transverse Myelitis

Based on a retrospective analysis of 71 patients with an neuromyelitis optica spectrum disorder (n = 37) or sarcoidosis (n = 34), whose initial presentation was longitudinally extensive transverse myelitis (≥ 3 vertebral segments), the authors report clinical, radiologic, and laboratory findings that help distinguish one from the other.

Carpal Tunnel Syndrome: Everything You Want To Know, and More

Carpal tunnel syndrome can be reliably diagnosed, only with nerve conduction studies, and this test should be performed before any invasive treatments are initiated.

Relationship Between Spikes and Seizures Using an Implantable Intracranial Detection Device

The authors report the preliminary findings for an implantable ambulatory intracranial recording device for seizure detection in 15 subjects. One of the primary findings was that spike rate significantly changed prior to seizures in nine of 15 subjects. Six of these subjects showed a significant decrease in spiking prior to ictal onset, whereas the remaining three showed a significant increase in spiking and these three subjects had the best seizure prediction results.

Clinical Characterization of Inherited Erythromelalgia Due to Sodium Channel Mutations

A detailed non-interventional clinical study of patients with inherited erythromelalgia who carry gain-of-function mutations of voltage-gated sodium channel Nav1.7 further characterized pain phenotypes in this disorder and showed wide variability of pain symptoms.

Clinical Briefs

In this section: examining autoimmune disorders associated with vitiligo; moderate alcohol consumption is not associated with reduced all-cause mortality; and rethinking the American diet.

Ixekizumab Injection (Taltz)

Ixekizumab is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Outcome of PCSK9 Inhibitor-treated Patients

In a meta-analysis of 17 studies, proprotein convertase subtilisin-kexin type 9 serine protease inhibitors markedly reduced low-density lipoprotein cholesterol levels and all-cause mortality, but was associated with a significant increase in neurocognitive adverse events.

Menopausal Hormone Therapy: Useful and Indicated for Vasomotor Symptoms

Menopausal hormone therapy is the most effective treatment for symptoms of the menopause, and benefits may exceed risks for most women within 10 years of menopause.