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Cerebral Microbleeds: Risk Factor for Symptomatic Intracerebral Hemorrhage

Cerebral microbleeds (CMBs), as visualized on gradient-echo or susceptibility-weighted MRI, are considered markers of bleeding-prone cerebral microvessels and constitute a significant and independent predictor of future intracerebral hemorrhage.

Buprenorphine Implant for Subdermal Administration (Probuphine)

The FDA has approved the first buprenorphine implant for the treatment of opioid dependence. Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Buprenorphine was previously approved as oral and sublingual tablets. The implant is marketed as Probuphine.

Human Adenovirus B7: Severe Infection

ABSTRACT & COMMENTARY: Patients with HAdV-B7 were more likely to be adults and to have longer hospital stays.

Dual Antiplatelet Therapy Appears More Effective Than Single Therapy

The CHANCE study showed that the combination of aspirin and clopidogrel was superior to aspirin alone for reducing the risk of stroke in the first 90 days after a TIA or minor ischemic stroke (N Engl J Med 2013;369:11-19).

Can Procalcitonin Predict Need for ICU Admission in Community-acquired Pneumonia Patients?

Several studies have focused on the use of procalcitonin in diagnosing sepsis, as a prognostic marker in sepsis, and as a guide to antibiotic decisions in sepsis.

Ticagrelor vs. Aspirin for Secondary Stroke Prevention — About the Same!

Ticagrelor was not found to be superior to aspirin in reducing the rate of stroke, myocardial infarction, or death within 90 days, but there was a trend toward a reduced rate of ischemic stroke, that did not reach statistical significance.

In Patients with Intracerebral Hemorrhage, Intensive Lowering of Blood Pressure Does Not Improve Outcome

intensive treatment of patients with intracerebral hemorrhage to achieve a target systolic blood pressure < 120 mmHg did not result in a lower rate of death or disability, but did result in an increased rate of renal adverse events.

Stiff-Person Spectrum Disorder: What Can Antibody Profiles Tell Us?

This retrospective study of 121 patients with stiff-person spectrum disorder extensively examined antibody correlates of clinical features. Anti-GAD65 antibodies were highly associated with typical stiff-person syndrome, and anti-GlyR antibodies with SPS-plus. However, presence of anti-GAD antibodies predicted worse outcome than presence of antiGlyR antibodies, independent of clinical subtype.

Structural and Functional Imaging ‘Phenotypes’ in Refractory Temporal Lobe Epilepsy Patients

Using high-resolution 3-T magnetic resonance imaging, temporal lobe epilepsy-hippocampal sclerosis showed significant preoperative ipsilateral volume loss, T2 hyperintensity, and mean diffusivity increases across all subfields, with the greatest effects seen anteriorly. However, temporal lobe epilepsy-gliosis showed increased volume in the dentate gyrus bilaterally, and more focal and subtle increases in T2 intensity and mean diffusivity.

What is the End Game in Creutzfeldt-Jakob Disease Progression?

Cerebellar and psychiatric symptoms at diagnosis of Creutzfeldt-Jakob disease may portend a higher risk for more rapid development of akinetic mutism.