Neurology
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Infective Endocarditis Trends and Outcomes
Using large databases from New York and California, investigators found the overall incidence of infective endocarditis remained stable between 1998 and 2013, and 90-day mortality declined. Changes were noted in pathogen etiology and patient characteristics over time.
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Clinical Briefs
In this section: Effects of weight gain on the cardiovascular system; comparing sleep apnea treatments; and rhabdomyolysis brought on by exercise.
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Edaravone Injection (Radicava)
The FDA has approved edaravone, the first new treatment for amyotrophic lateral sclerosis since the approval of riluzole more than 20 years ago.
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Guillain-Barré Syndrome and Hepatitis E
Hepatitis E is the most common form of viral hepatitis worldwide and often is asymptomatic, but it is commonly associated with Guillain-Barré syndrome and Guillain-Barré variants.
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Treatment of Chronic Fatigue/Myalgic Encephalitis Syndrome
Blockade of IL-1 activity with anakinra failed to reduce fatigue in patients with chronic fatigue syndrome.
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Very Low-carbohydrate Ketogenic Diet May Reverse Type 2 Diabetes
A very low-carbohydrate ketogenic diet demonstrated superiority to the plate method diet recommended by the American Diabetes Association for controlling and even reversing type 2 diabetes.
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No Single Solution to Prevent Medication Nonadherence
Simple, low-cost reminder pill bottles did not lead to more improvement in medication adherence in patients with documented poor adherence.
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Should the Treatment Response Cause Alarm?
The rhythm in the figure was observed as a previously healthy young adult was receiving treatment for the patient described as 'palpitations.'
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Clinical Briefs
In this section: drug therapy for diabetes; timing surgical knee and hip replacement; and treating low back pain.
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Brigatinib Tablets (Alunbrig)
Brigatinib is indicated for the treatment of patients with anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib.