Neurology
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Alcohol Consumption and Migraine
In this observational, cross-sectional survey performed via an online questionnaire, researchers confirmed that alcohol consumption is a common trigger for migraine, and red wine is the type of alcohol cited as a trigger most frequently.
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REM Behavior Disorder, Dementia, and Parkinson’s Disease
In this well-designed prospective cohort study of patients with REM behavior disorder, the investigators reported that 73.5% of patients developed a neurodegenerative disorder after a 12-year follow-up.
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MRI Investigation of Brain Abnormalities in Friedreich’s Ataxia
Friedreich’s ataxia (FRDA) is characterized by progressive weakness, sensory loss, ataxia, and dysarthria starting in childhood. The authors of this MRI-based study demonstrated that structural damage is limited to the spinal cord, red nucleus, and cerebellar peduncles in young FRDA patients, but progresses to widespread cerebral damage in adult FRDA patients.
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Brexanolone Injection (Zulresso)
Brexanolone is indicated for the treatment of postpartum depression.
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Update on Treatments for Vulvovaginal Atrophy
As with many clinical conditions, the spectrum of genitourinary syndrome of menopause requires the clinician to consider the effect on the patient’s quality of life. Although situational lubricants and regular moisturizers effectively pacify many symptoms, local estrogen is a safe, effective, and affordable way to treat the vulvovaginal changes of menopause.
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Imagine: Multidrug-Resistant Acute Gonococcal Infection
What would happen if clinicians lost ceftriaxone as an effective therapy for gonococcal infection?
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Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients
A retrospective cohort study from a single California hospital revealed the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.
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Does Physical Activity Lower the Risk of Parkinson’s Disease?
A systematic review and meta-analysis incorporating more than 500,000 subjects revealed that moderate to vigorous physical activity is associated with a significant reduction in development of Parkinson’s disease; this relationship is most pronounced in men.
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Is There AV Block?
The long lead II rhythm strip in the figure was recorded at the standard 25 mm/second speed. This tracing was obtained from a middle-aged woman who presented to an outpatient clinic with noncardiac chest pain. How would one interpret this rhythm? Are there signs of AV block? Is it apparent if there is a cardiac problem?
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Esketamine Nasal Spray (Spravato) CIII
Esketamine, in conjunction with an oral antidepressant, is indicated for the amelioration of treatment-resistant depression in adults.