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Anti-ganglioside peripheral nerve antibodies in Guillain-Barré syndrome (GBS) include GM1, asialo-GM1, GQ1b, GD1a, and GT1a. GM1 is associated with pure motor GBS and with the acute motor axonal variant of GBS. GM1b is also associated with GBS, but often its role in the disease is obscured by the concomitant presence of GM1. The role of GM1b in the absence of GM1 remains to be defined.
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Two recent reports strongly suggest that Elans AN-1792 Alzheimers vaccine, which was withdrawn from clinical trials after several Alzheimers disease (AD) patients developed severe brain inflammation, did in fact succeed in altering the course of AD in some cases.
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Intracranial balloon angioplasty and stent placement now are available to patients suffering from intracranial stenosis that involves the vertebrobasilar arteries (VBA). At present, however, no consensus exists regarding the role of endovascular procedures vs best medical management.
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In this original study, 500 consecutive pediatric referrals for neurologic consultation were assessed to determine what influence, if any, was played by the history, neurologic examination, and investigations, with respect to final diagnosis and patient management.
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Filippi and colleagues performed conventional brain MRIs and whole-brain N-acetylaspartate (WBNAA) measurements with proton magnetic resonance spectroscopy in 31 patients presenting with clinically isolated syndromes suggestive of multiple sclerosis (MS).
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The Women's Health Initiatives (WHI) was halted 1 year ago, but fallout from this landmark study continues. The study was designed to identify the risks or benefits of estrogen plus progesterone vs placebo in healthy postmenopausal women.
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This study concludes that there may be a direct association between ischemia and the development of Alzheimers pathology (plaques and neurofibrillary tangles), or alternatively, ischemia may unmask otherwise mild cases of AD.
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The management of the obesity epidemic is complex, but there are some interventions that can be helpful.
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Although the phenomenon of cutaneous melanoma (CM) arising from melanocytic nevi (MN) is known, the transformation rate of MN into CM is not. Tsao and associates set out to calculate the rate, using published data and making some assumptions to ease the calculation.
