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Alefacept is a new biological agent for the treatment of moderate-to-severe plaque psoriasis. The drug, which targets T lymphocytes, is a fusion protein combining the binding site of lymphocyte function-associated antigen-3 and the Fc portion of human IgG1.
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This article reviews the pathophysiology involved in the newborn with congenital heart disease and familiarizes the reader with the nomenclature and known complications encountered in the care of these children.
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This article, the second of two parts, deals with the potentially disastrous situation in which either the patients airway presents a substantial challenge or standard intubation methods have failed.
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The demographics of our foreign-born population have undergone a polar shift during the past 50 years. Europeans once made up the majority of new arrivals, but Asians and Latin Americans now predominate. Part II of this series will familiarize physicians with some of the infections and diseases specific to immigrants from particular regions of the world.
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Synopsis: The clinical decision rule tested in this study reduced unnecessary hospital admissions in patients with suspected acute cardiac ischemia without affecting safety.
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In a recent issue of Critical Care Alert I discussed the epidemiology and pathophysiology of invasive fungal infections that afflict patients in the ICU. In this issue, I review the current treatment options.
