Browse Neurology Topics Articles by Topic

Determinants of Long-Term Outcome After Concussion

This cohort study of U.S. veterans found that mild traumatic brain injuries occurring alongside psychological trauma are associated with long-term post-concussive symptoms and disability. The authors postulate that the traumatic context contributes to the development of post-traumatic stress disorder, which may in turn potentiate long-term sequelae.

Transcranial Magnetic Stimulation and Tai Chi for Older Adults with Sleep Disorders and MCI

This study showed improvement in sleep and cognitive endpoints in patients with sleep disorders and mild cognitive impairment (MCI) treated with a combination of repetitive transcranial magnetic stimulation and tai chi chuan.

Transfusion Therapy in Aneurysmal Subarachnoid Hemorrhage

The SAHARA trial evaluated liberal vs. restrictive red blood cell transfusion strategies in aneurysmal subarachnoid hemorrhage (SAH) patients with anemia. No significant difference in neurological outcomes at 12 months was found. Findings add to existing uncertainty regarding transfusion thresholds in SAH, highlighting the need for further research.

Diagnosis and Outcome of Reversible Cerebral Vasoconstriction Syndrome

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare disorder characterized by thunderclap headaches and cerebral vasoconstriction resolving within 90 days. A retrospective study of 80 patients found favorable outcomes, with most treated using calcium channel blockers. However, challenges in RCVS diagnosis and classification may affect reported outcomes.

Clinical, Biological, and Imaging Features of Intravascular Large B-Cell Lymphoma

A multicenter, retrospective cohort study of 17 patients with pathology-proven intravascular lymphoma involving the central nervous system identified “red flag” clinical features, imaging patterns, and cerebrospinal fluid characteristics that may help expedite the diagnosis of this rare, complex, and deceptive disease.

ABCD² Score as a Predictor of Three-Year Stroke Risk

This retrospective cohort study using the National Patient Registry in Denmark analyzed a three-year follow-up period following a transient ischemic attack, looking at the rate of recurrent stroke and mortality. The patients were divided into low risk (ABCD² score 0-3) and high risk (ABCD2 score ≥ 4). The stroke rate was 6% in the high-risk group and 4% in the low-risk group.

Modifiable Cardiovascular Risk Factors and Late-Life Brain Health

The major modifiable risk factors for cardiovascular diseases are delineated in Life’s Essential 8 (LE8), developed by the American Heart Association. These risk factors are blood pressure, glucose, cholesterol, body mass index, smoking, physical activity, diet, and sleep duration. The investigators in this analysis of two large databases in the United Kingdom and the United States, demonstrated that cardiovascular health, as defined by the LE8, will also predict brain health later in life.

Migraine and Ischemic Vascular Disease: The Search for the Missing Link

The presence of traditional vascular risk factors does not explain the increased incidence of ischemic stroke and myocardial infarction in patients with migraine. The use of nonsteroidal anti-inflammatory drugs does not increase the risk of ischemic stroke or myocardial infarction in migraineurs.

Wildfire Smoke Exposure Is a Risk Factor for Dementia

In this large, open cohort study based on electronic health record data from 2009 to 2019 of dementia-free people older than 60 years of age, exposure to wildfire smoke resulted in an increased incidence of dementia later in life.

Psychiatric Comorbidities in Persons with Epilepsy

In this systematic review and meta-analysis, the prevalence of most psychiatric disorders was significantly higher in persons with epilepsy than in those without epilepsy. These findings show the high burden of psychiatric comorbidities in persons with epilepsy and underscore the importance of appropriately identifying and treating psychiatric comorbidities in epilepsy patients.