Neurology Alert
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Predicting Coma Recovery in Critically Ill COVID-19 Patients
The COVID-19 pandemic presented us with an unprecedented number of critically ill patients with coma. These investigators determined that the degree of hypoxemia determined the depth and duration of coma, but recovery was much better than expected and could be delayed by several weeks.
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Treatment of Acute Vertigo
In a meta-analysis of published studies of treatment of acute vertigo, the authors concluded that treatment with an antihistamine is more effective than benzodiazepines for the acute symptoms. However, there was no difference between the two medications in terms of resolution within one week or within one month.
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Researchers Explore Connections Between Epilepsy and Postpartum Anxiety, Depression
Clinicians should monitor for signs of depression among patients with epilepsy who are pregnant or patients who are thinking about conceiving.
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COVID-19 and Headache
Headache is a common feature of acute COVID-19 infection, as well as a long-standing feature of “long COVID” after recovery from the acute infection. Treatment is symptomatic, based on the characteristics of the headache syndrome.
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Myopathy Is Associated with Post-COVID-19 Fatigue
Prolonged fatigue after COVID-19 infection may be associated with evidence of myopathy, based on physical examination, electromyography, and muscle biopsy.
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Risk Factors Associated with Alzheimer’s Disease and Related Dementias in the United States
Two independent analyses of U.S. national surveys support evidence that targeted risk-reduction strategies may reduce the burden of Alzheimer’s disease in the population.
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Noradrenergic Drugs for the Symptomatic Treatment of Alzheimer’s Disease
This meta-analysis provides evidence that drugs modulating the noradrenergic system could be effective in treating cognitive symptoms and apathy in patients with Alzheimer’s disease.
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Does Tranexamic Acid Treatment of Acute Intracerebral Hemorrhage Cause Ischemic Stroke?
Acute spontaneous intracerebral hemorrhage is one of the least treatable forms of stroke. Tranexamic acid now is being studied as a hemostatic agent in spontaneous intracerebral hemorrhage. However, similar to the use of other antifibrinolytic drugs, there is concern that there may be ischemic complications from this treatment, including ischemic stroke.
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Endovascular Thrombectomy with or Without Alteplase? Get With The Guidelines
Since 2015, endovascular thrombectomy with intravenous alteplase has been the standard of care for patients with large vessel occlusion and ischemic stroke. However, since that time, the continuing use of alteplase has been questioned by many practitioners and investigators.
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Mechanical Thrombectomy with or Without Intravenous Thrombolysis?
Current stroke treatment guidelines recommend combined use of intravenous thrombolysis with alteplase prior to endovascular thrombectomy for patients with large vessel occlusion. However, there continues to be controversy surrounding this recommendation, and these investigators undertook a systematic review and meta-analysis of completed therapeutic trials to help resolve the controversy.