Browse Neurology Alert Articles by Topic

Misdiagnosis of Autoimmune Encephalitis

A recent multicenter, retrospective review of 393 adult patients given a diagnosis of autoimmune encephalitis noted that 107 patients (27%) were misdiagnosed and ultimately had other diagnoses confirmed, but after a considerable delay.

Long-Term Statin Use Associated with Lower Stroke Risk

A cohort of Danish patients who were taking the cholesterol control medication were less likely to experience an intracerebral hemorrhage.

Can Artificial Intelligence Help Us to Choose the Best Anti-Seizure Medicine?

A new deep learning artificial intelligence algorithm was able to identify the most effective initial drug to treat newly diagnosed epilepsy, compared to the physicians’ clinical judgment. The algorithm required prospective, carefully collected clinical data for its success.

Lipid Pathway Dysfunction in Parkinson’s Disease

In this large-scale study, the authors used a comprehensive untargeted lipidomic approach to determine the extent to which lipid dysregulation occurs in patients with Parkinson’s disease generally and in mutation carriers of one of the most common Parkinson’s disease risk genes, LRRK2. Further pathway analysis reveals sphingolipid metabolism, insulin signaling, and mitochondrial function as major metabolic pathways dysregulated in Parkinson’s disease.

Influence of Vitamin Intake on the Prevalence of Migraine

In a large population-based survey, 21.6% of participants reported having severe headaches or migraine. Those reporting severe headaches also reported a lower intake of thiamine and riboflavin, based on 24-hour recall of food intake. There also was an inverse relationship between thiamine intake and reports of severe headaches.

Atypical Presentations for Inclusion Body Myositis

Inclusion body myositis, the most common acquired myopathy, often is misdiagnosed or diagnosed after a delay of many years. Atypical presentations are not unusual, and clinicians should maintain a high degree of suspicion for this disorder when patients present with slowly progressive muscle weakness in an unusual pattern.

Early Respiratory Decline in Amyotrophic Lateral Sclerosis

Hypercapnia, a manifestation of early respiratory dysfunction, can be challenging to detect in amyotrophic lateral sclerosis (ALS) patients. Pulmonary function tests are helpful, but their specificity in detecting hypercapnia is low and their use is limited in patients with bulbar weakness. Specific symptoms, such as dyspnea at rest, dyspnea while talking, and use of medications for sleep, can be more reliable in detecting hypercapnia among ALS patients.

Persistent Asthma Patients Show More Plaque Buildup, Inflammation

Pulmonary ailment could speed carotid artery damage, create more inflammatory biomarkers.

Scientists Are Worried About Air Quality and Dementia Risk

Traffic-related air pollution raises red flags for neurological health.

Long-Term Neurological Outcomes of Patients Treated with CAR-T Therapy

Chimeric antigen receptor (CAR)-T cell therapy is approved for the treatment of lymphoma, leukemia, and multiple myeloma, but its use is associated with early neurotoxicity in almost half of patients. Despite the incidence of neurotoxicity, long-term follow-up of patients after CAR-T infusion suggests that patients’ neurological examination, neuro-imaging studies, and cognition remain unaffected by this treatment.