Multiple Sclerosis
RSSArticles
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Childhood Head Trauma and Risk of Subsequent Diagnosis of Multiple Sclerosis
A large study that reviewed longitudinally collected data from the national Swedish Patient Register found that head trauma in adolescents was associated with an increased risk of subsequent diagnosis of multiple sclerosis.
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Exploring Cortical Pathology in Multiple Sclerosis With Routine MRI
In this MRI and histopathological study, the investigators showed that cortical T1w/T2w ratio was unrelated to myelin density, but had a strong correlation with dendritic density. Furthermore, abnormal values within the posterior cingulate cortex correlated with impairment in cognitive domains.
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Disability in Patients with Multiple Sclerosis: A Long-Term Study
SYNOPSIS: In a long-term study, the rate of disability progression in treated relapsing and progressive, multiple sclerosis patients was lower than that reported in earlier natural history studies.
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Disease Rebound After Stopping Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis
A review of patients with relapsing-remitting multiple sclerosis who discontinued fingolimod therapy showed that five out of 46 (10.9 %) of these patients developed a rebound phenomenon between 4 to 16 weeks, where disease activity returns and often exceeds pre-treatment levels.
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Biomarkers of Intrathecal Inflammation in Multiple Sclerosis and Other Disorders
A study of intrathecal immune markers in neuro-immunological diseases revealed increased numbers of activated T and B cells in both relapsing and progressive multiple sclerosis, but they were preferentially embedded in the brain tissue in progressive multiple sclerosis.
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Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS
Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.
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Is Pediatric-onset Multiple Sclerosis a Neurodegenerative Disorder?
ABSTRACT & COMMENTARY: Pediatric-onset multiple sclerosis compromises age-expected brain growth.
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When Is it Best to Evaluate the Results of a CSF Tap Test?
The tap test has variable results as a tool to assess patients with a presumed diagnosis of normal pressure hydrocephalus. -
Rituximab May Be Effective for Refractory Myasthenia Gravis
In a restrospective review, rituximab appeared beneficial for patients with medication-resistant myasthenia gravis. -
Pharmacology Watch
New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions.