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National organizations filed amicus briefs in two federal cases centered on a law enacted in Washington, DC.
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In this post hoc analysis of the SPICE III trial, a greater percentage of patients receiving dexmedetomidine had temperatures greater than or equal to 38.3ºC and 39.0ºC compared to usual care. Although there was a significant dose response relationship between dexmedetomidine received and increase in temperature, there was no difference between groups in terms of paracetamol, antimicrobial, neuromuscular blocker, neuroleptic drug use, blood cultures performed, or initiation of renal replacement therapy.
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Using newer methodology in network meta-analysis to compare various protective mechanical ventilation strategies, the authors concluded that a low tidal volume strategy combined with prone ventilation was associated with the greatest risk reduction in mortality for moderate to severe acute respiratory distress syndrome.
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Biomarkers have become an important tool for the early recognition and prognostication of acute kidney injury. In the last few years, several biomarkers have emerged that have shown promising results in large-scale clinical studies.
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Finerenone can be prescribed to lower the risk of sustained estimated glomerular filtration rate decline, cardiovascular death, non-fatal myocardial infarction, end-stage kidney disease, and hospitalization from heart failure in adults with chronic kidney disease associated with type 2 diabetes.
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In this retrospective, cross-sectional study of men, both sleepwalking and rapid eye movement sleep behavior disorder were associated with the development of Parkinson’s disease.
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There is a significant increase in dementia risk associated with the use of anticholinergic medications for three months or longer.
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Saccharomyces boulardii is a probiotic yeast that may cause fungemia and other fungal infections.
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The authors review chromium, cinnamon, fenugreek, garlic, and Gymnema sylvestre as complementary and alternative medicine supplements for managing type 2 diabetes.
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Patients with three-vessel or left main coronary artery disease randomized to coronary bypass surgery vs. percutaneous therapy on optimal medical therapy at five years with three or four of the recommended drugs recorded a lower 10-year all-cause mortality rate vs. those on ≤ 2 drugs.
