Internal Medicine
RSSArticles
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Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis
This retrospective study of autologous hematopoietic stem cell transplantation in patients with active relapsing remitting multiple sclerosis or progressive multiple sclerosis showed efficacy in relapse rate reduction and on magnetic resonance imaging and disability outcomes during a median post-transplant follow-up of about two years. There were risks, including death, associated with the treatment.
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Diagnostic Utility of CSF Alpha-Synuclein
This observational study investigated whether the cerebrospinal fluid (CSF) α-synuclein (α-syn) real-time quaking-induced conversion (RT-QuIC) assay, applied to 289 CSF samples, accurately identified patients with mild cognitive impairment (MCI) caused by probable Lewy body (LB) disease. RT-QuIC identified patients with MCI-LB against cognitively unimpaired controls with 95% sensitivity, 97% specificity, and 96% accuracy and showed 98% specificity in neuropathologic controls, indicating that CSF α-syn RT-QuIC is a robust biomarker for prodromal dementia with Lewy bodies.
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Surgical Approaches to Decompression in Degenerative Lumbar Spondylolisthesis
A multicenter, randomized, noninferiority trial of people with symptomatic lumbar stenosis and single-level spondylolisthesis who were refractory to conservative treatment found no significant difference between outcomes in those who underwent decompression surgery with instrumented fusion vs. decompression surgery without fusion.
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Adverse Effects of Electronic Cigarettes on the Disease-Naïve Oral Microbiome
A robust metagenomic comparison study of the effects of electronic cigarettes on oral microbiomes suggested the unique aerosol component of electronic cigarettes poses increased risk to development of oral cavity disease.
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Aftermath of COVID-19 in Adults
This review of investigations centered on long-term effects following acute COVID-19 illness in adults illustrates an evolving understanding of the aftermath of this viral infection.
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Electronic Cigarette Use and Risk of Lung Injury
Electronic cigarette use has increased rapidly. Although vaping may aid with stopping cigarette smoking, cases of severe pulmonary disease and several deaths related to vaping have been reported.
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Infectious Disease Alert Updates
Pyrethroids losing activity against mosquitoes; Resistance erodes standard treatment for pneumonia; and homelessness and COVID-19.
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SARS-CoV-2 Rapid Antigen Testing in a Nursing Home Outbreak
Rapid antigen testing was accurate in detecting SARS-CoV-2 antigen when compared to polymerase chain reaction.
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Well-Appearing Febrile Infants: New Guidelines for Evaluation and Management
New guidelines provide specific recommendations for the use of diagnostic testing, antimicrobial treatment, and ongoing care based on age for children between 8 and 60 days of age.
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.