Internal Medicine
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Resistance Erodes Standard Treatment for Pneumonia
These data suggest community-acquired pneumonia CAP therapy may no longer be relevant for many patients with CAP, and the required use of the current CAP bundle with limited antibacterial therapy choices should be re-assessed.
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Overdiagnosis of Chronic Kidney Disease in the Elderly
Older patients experience a physiological decline in estimated glomerular filtration rate. However, if the same levels are used to define chronic kidney disease for all adults, older patients not at a higher risk for kidney failure might still be classified with the disease.
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Left-Sided Breast Cancer Radiation Therapy and Coronary Artery Disease
A study of breast cancer survivors revealed left breast radiation therapy doubles the subsequent risk of coronary heart disease vs. right-sided radiation.
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Long-Term Post-TAVR Survival and Permanent Pacemaker Implantation
An analysis of a real-world database revealed 14% of patients undergoing routine transfemoral transcatheter aortic valve replacement required permanent pacemaker implantation within 30 days of the valve procedure. There was no difference in long-term survival between patients who did and did not undergo pacemaker implant.
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Importance of Age in the Application of Coronary Artery Calcium Detection
Using coronary CT strategy as a diagnostic first line in patients with symptoms suggestive of coronary artery obstruction revealed relying on the coronary calcium score alone is inadequate for younger patients with a higher frequency of non-calcified obstructions.
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Coronary CT Angiography in the General Population
Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.
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Intensive Monitoring for Asymptomatic Atrial Fibrillation Did Not Prevent Strokes
Screening with an implantable loop recorder resulted in dramatically higher rates of atrial fibrillation detection and ensuing anticoagulation, but without a significant decrease in risk of stroke or systemic embolism by six years of follow-up.
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Cost to Treat U.S. Patients with Rare Diseases Likely Underestimated
NIH, FDA, other groups form consortium to speed gene therapy development.
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Antibiotics for Appendicitis, Revisited
One year later, researchers present updated data that strengthen the alternative to surgery approach.
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Regulators Sign Off on COVID-19 Vaccine ‘Mix and Match’
Federal agencies expand, clarify guidance on booster shots.