Internal Medicine
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Cardiopulmonary Exercise Testing and Survival in Systolic Heart Failure
A large study of patients with chronic systolic heart failure undergoing cardiopulmonary exercise testing found peak oxygen uptake, exercise duration, and percent predicted peak oxygen uptake were the strongest predictors of survival.
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Prognostic Value of Coronary Calcium on Standard Chest CT Scans
Coronary calcium scan on standard CT scans performed for other indications is of equivalent prognostic value to that seen on ECG-gated coronary studies and should be included in radiology test reports.
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TAVR Still a Viable Option for Many Left Main Disease Patients
Performing planned left main percutaneous intervention before or during transcatheter aortic valve replacement does not confer increased risk of short- or intermediate-term adverse outcomes.
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Outcome of PCSK9 Inhibitor-treated Patients
In a recent study, proprotein convertase subtilisin-kexin type 9 serine protease inhibitors significantly improve lipid profiles and reduce all-cause mortality, but were associated with more neurocognitive adverse events than placebo.
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Potatoes Increase Risk of Type 2 Diabetes Mellitus
Few would question the recommendation to increase daily vegetable intake. Yet, an important question arises — are all vegetables created equal?
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Why We Can’t Allow Physical Exam Skills to Languish
With more highly evolved and readily available technology at our fingertips, it is sometimes tempting to let the echocardiogram sort out the abnormal heart sounds we detected, or allow the pelvic ultrasound to inform whether the uterus is enlarged, or short-cut parts of the physical exam we anticipate to be unlikely sources of pertinent information.
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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Does Finding the Portal of Entry of Bacteria in Infective Endocarditis Matter?
A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful and affords an opportunity to prevent recurrent episodes.
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Does the Use of Saline vs Buffered Crystalloid Reduce Risk of Acute Kidney Injury in ICU?
The use of a buffered crystalloid compared with saline did not reduce the risk of acute kidney injury in patients receiving crystalloid fluid therapy in the ICU.
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Effects of a Rapid Response System Driven by Real-time Automated Clinical Alerts
The addition of an automated real-time clinical deterioration alert system to a rapid response system had marginal effects.