Internal Medicine
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Antibiotics and Adverse Events: Doctors, Do No Harm
A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 of the antibiotic regimens were not clinically indicated, and 56 of these were associated with an adverse drug event.
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Are Right-sided Leads Needed?
The ECG in the figure was obtained from a man in his 50s who presented with new severe chest pain. How would you interpret this tracing? What area(s) of the heart are involved? What is the likely culprit artery?
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Clinical Briefs
In this section: opioid-induced nausea; considering the safety of proton pump inhibitors; and life after bariatric surgery.
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Secnidazole Oral Granules (Solosec)
Secnidazole is indicated for the treatment of bacterial vaginosis in adult women.
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Oily Fish Is Associated With Better Sleep
A study in Ecuador showed a strong positive correlation between dietary oily fish intake and sleep quality.
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A Rivaroxaban/Daily Low-dose Aspirin Combination and Cardiovascular Events
The addition of rivaroxaban to daily low-dose aspirin resulted in fewer cardiovascular outcomes and increased major bleeding compared to aspirin alone in patients with stable cardiovascular disease.
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A Cup of Coffee May Help Patients Live Longer
In a prospective cohort of patients coinfected with HIV and hepatitis C virus, drinking three or more cups of coffee per day halved the all-cause mortality risk.
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Migraine With Aura, Stroke Risk, and Biomarkers
A longitudinal cohort study of twins found no increased stroke risk related to migraine overall, but there was a modestly increased risk for stroke related to migraine with aura. Familial factors and vascular biomarkers associated with migraine with aura may explain its correlation with vascular disease.
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Diabetes, HbA1c, and Neuropathy
The hallmark of neuropathy associated with type 2 diabetes is reduction of sensory nerve action potential amplitude and not a reduction in conduction velocity, supporting the hypothesis that hyperglycemia causes axonal dysfunction and injury.
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Noninvasive Vagus Nerve Stimulation for Indomethacin-Sensitive Headaches
Trigeminal autonomic cephalgias are notoriously difficult to treat and may be responsive to noninvasive vagus nerve stimulation.