Browse Internal Medicine Articles by Topic

Nonhormonal Treatment for Menopausal Vasomotor Symptoms: A Phase III Study of Fezolinetant

More than 500 women with moderate to severe menopausal vasomotor symptoms received either 45 mg of fezolinetant, 30 mg fezolinetant, or placebo. Both fezolinetant doses significantly reduced the frequency and severity of menopausal symptoms at four and 12 weeks of treatment vs. placebo.

Supine Blood Pressure Readings May Reveal Hidden Health Risks

Measuring a patient’s blood pressure while he or she is lying down could help clinicians learn more about possible underlying heart problems.

Syncope and Complete AV Block?

The rhythm strip shown in the figure was recorded from a patient with syncope. It was interpreted as consistent with complete AV block. Do you agree with that interpretation?

Zuranolone Capsules (Zurzuvae)

Zuranolone can be prescribed to treat postpartum depression.

The Degree of Pyuria Can Help Determine Urinary Tract Infection in Elderly Women

Elderly women with a urinary tract infection recorded a higher median number of urinary leukocytes compared to uninfected controls, including those with asymptomatic bacteriuria. For 264 leukocytes/µL, the sensitivity and specificity of microscopy were 88%. Using the standard pyuria threshold of 10 leukocytes/µL gave a specificity of 36% and a sensitivity of 100%.

Treating Psychotic Symptoms Among Alzheimer’s Disease Patients

In a meta-analysis of several large treatment trials of patients with Alzheimer’s disease, Parkinson’s disease, and dementia with Lewy bodies, cholinesterase inhibitors demonstrated a small but statistically significant benefit in alleviating psychotic symptoms.

Comparing Sequelae After Hospitalization with COVID-19, Influenza, or Sepsis

The incidence of most selected new-onset medical conditions did not significantly differ among those who had been hospitalized with COVID-19, influenza, or sepsis.

Reconsidering Aspirin Therapy for Elderly Patients

A post-hoc analysis of the ASPREE trial revealed that in presumably healthy elderly subjects, taking low-dose aspirin daily over three years was associated with a significant drop in hemoglobin and ferritin levels vs. placebo, even when patients with major bleeding events were excluded.

Biden Administration Releases 10 Drugs for Price Negotiation

Medications represent 20% of the total Medicare Part D gross covered prescription costs.

Social Determinants Play Outsized Role in Black/White Cardiovascular Health Gap

Lower income levels, less education, tighter insurance access raise risk for cardiovascular disease mortality.