Internal Medicine
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Tolvaptan Tablets (JYNARQUE)
Tolvaptan is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease.
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Rapid Screening for Future Risk of Parkinson’s Disease Dementia
The Montreal Parkinson Risk of Dementia Scale provides a simple eight-item screening tool with high predictive value for developing Parkinson’s disease dementia.
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Combined Treatments with Medications for Hypertension and Hyperlipidemia Dramatically Reduce the Risk of Stroke
In this real-world study, fixed-dose candesartan/hydrochlorothiazide combined with low-dose rosuvastatin reduced first stroke by 44% in patients at intermediate risk of cardiovascular disease and was well tolerated, with minimum dropout of patients.
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Chiropractic Spinal Manipulation for Migraine
Chiropractic spinal manipulation offers no benefit over placebo for migraineurs.
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The Pulmonary Embolism Rule-out Criteria in Low-risk Patients
A cluster randomized trial of the pulmonary embolism rule-out criteria (PERC) compared to usual care for patients estimated to be at low risk of pulmonary embolus (PE) in EDs showed that PERC was non-inferior to usual care at identifying patients who would be free of symptomatic PE at three months, resulting in less use of healthcare resources.
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Saffron as Adjunctive Therapy for Opioid Withdrawal
A small, poorly designed study hints at some adjunctive treatment benefit for saffron powder in people weaning off narcotic medications.
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Mindfulness-based Intervention in Patients With Generalized Anxiety Disorder
Reductions in stress markers for patients with generalized anxiety disorder were found using mindfulness-based stress reduction intervention.
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Tai Chi or Aerobics: Which Is Better for Fibromyalgia?
In this randomized, controlled trial, researchers found that tai chi shows equal or greater effect than aerobic exercise for addressing symptoms of fibromyalgia, and that more effect is obtained with longer duration of tai chi practice.
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Dairy Intake and Risk of Parkinson’s Disease
Frequent consumption of dairy products is associated with a modest increased risk of Parkinson’s disease (PD) in women and men. In addition, intake of high-fat dairy is associated with decreased risk of PD.
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Diabetic Retinopathy, Associated Comorbidities, and Treatment Considerations
Diabetic retinopathy is a complex disorder of the microvascular and neuronal structure of the retina. Although poorly understood, the problem does not start in the retina, but rather begins through systemic metabolic dysfunction, which causes damage to retina vessels. This article will review the structure of the retina, the systemic pathophysiology of diabetes, the resulting damage to retinal structure and function, comorbidities, traditional treatments, and prevention and treatment for diabetic retinopathy and its comorbidities.