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Goiter literally means the enlargement of the thyroid gland, independent of its cause. Historically, this terminology specifically was reserved for a visibly enlarged thyroid gland. During the past few decades of modern medical practice, the term has come to include both visible as well as palpable thyroid enlargement. This article will review the pathophysiologic processes leading to goiter formation and will provide a logical approach to the diagnosis and management of different entities, the end result of which is an enlarged thyroid gland.
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Oral rofecoxib (Vioxx) may have a role in controlling postoperative pain patients undergoing knee surgery.
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This monograph provides an overview of allergic disorders and reviews the current understanding of the mechanism of the allergic response. Due to the extensive nature of the topic, the discussion has been limited to systemic reactions eliciting an IgE-mediated response. Further, the intimate relationship between organs involved is reviewed, particularly the relationship between allergic rhinitis and asthma.
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The first head-to-head comparison study of an ACE inhibitor and an angiotensin receptor blocker, to assess renoprotective effects in type 2 diabetes, has shown that the drugs are comparable in their benefit.
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Arguably the most important new trial to be reported in New Orleans was the African-American Heart Failure Trial; the use of a combination of isosorbide dinitrate and hydralazine in African-Americans with congestive heart failure.
