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Predicting the Progression of Chronic Aortic Regurgitation

A large database observational study of patients with chronic aortic mild or moderate regurgitation (AR) largely due to bicuspid aortic valve or aortic root dilatation showed that it was largely an indolent disease, with only 20% progressing to moderately severe AR in five years.

Perioperative Management of Direct Oral Anticoagulants

A simple protocol for managing atrial fibrillation patients on direct oral anticoagulants perioperatively was shown to produce low levels of major bleeding and thromboembolism for 30 days postoperatively.

CRT Nonresponders Experience Poor Outcomes, Warrant More Aggressive Management

The ADVANCE CRT registry revealed a significant minority of patients fail to respond to cardiac resynchronization therapy, conferring a worse prognosis.

Is the Physical Exam an Anachronism in Heart Failure?

In the PARADIGM-HF trial, signs of congestion during physical exam were related to outcomes and the improved outcomes observed with valsartan/sacubitril vs. enalapril.

CABG vs. PCI for Left Main Disease at 5 Years

Five years after randomizing 1,905 patients with left main disease to coronary artery bypass grafting or percutaneous coronary intervention, researchers found no significant difference in the primary composite outcome of death, stroke, or myocardial infarction.

Why Was There Syncope?

The 12-lead ECG in the figure was obtained from a middle-aged woman with syncope and hypotension but no chest pain. No long lead rhythm strip is available. What might be causing her syncope?

Omeprazole Magnesium, Amoxicillin, and Rifabutin Delayed-Release Capsules (Talicia)

Talicia is indicated for the treatment of Helicobacter pylori infection in adults.

Urine Cultures: A Gateway to Antibiotic Overuse

Inappropriate antibiotics use in nursing homes across North America continues driving antibacterial resistance and the risk of Clostridioides difficile infection in the elderly.

Consensus Position Statement on the Use of Testosterone in Women

A task force of representatives from leading international societies issued guidance for appropriate prescribing of testosterone in women.

Sexually Transmitted Diseases in the United States — Not a Happy Picture

Since reaching historically low rates, many sexually transmitted infections have re-emerged in the United States. Of particular concern is the continued emergence of antibiotic resistance in Neisseria gonorrhoeae.