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In March 2014, Ebola virus infection emerged in Guinea, West Africa, and spread through communities in Guinea and Liberia. Additional reports of suspect cases in Sierra Leone and Mali are under investigation.
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In an observational study of 205 patients with bloodstream infections caused by strains of carbapenemase-producing Klebsiella pneumoniae, mortality was higher in patients who received monotherapy vs. those treated with combination therapy (44.4% vs 27.2%, P = 0.018).
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There have been several advances in medical understanding of the prevention, diagnosis and treatment of CDI since the last national guidelines were published in 2010.
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Oculopharyngeal muscular dystrophy is a rare, autosomal dominant neuromuscular disorder that has recently been genetically defined and may be treatable with myoblast transplantation.
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Hemicraniectomy in Older Patients with Large Middle Cerebral Artery Infarcts Reduces Mortality
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This well-designed, randomized, controlled trial, which included a sham arm, showed no evidence for the efficacy of hyperbaric oxygen therapy to treat the symptomatic, cognitive, and behavioral sequelae of postconcussion syndrome in soldiers after combat-related mild traumatic brain injury.
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Chronic use of sleeping medications, particularly benzodiazepines, is associated with an increase in all-cause mortality, and should be avoided if at all possible.
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A Phase 2 trial of atacicept, a humanized recombinant protein that suppresses B cell function, demonstrated a negative impact on clinical disease activity in relapsing-remitting multiple sclerosis.
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Blood Pressure Variability May Predict Poor Outcome After Intracerebral Hemorrhage
