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Uk-427,857 (Maraviroc) is an investigational small-molecule HIV entry inhibitor that binds to the CCR5 chemokine receptor on the surface of T-cells. This chemokine receptor is normally the receptor for the chemokines MIP-1 alpha and RANTES.
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Treatment of chronic Hepatitis B is directed at suppressing viral replication, reducing hepatitis (necroinflammatory) activity, slowing progression of fibrotic disease, inducing loss of HBeAg with seroconversion to anti-HBe, and rendering patients noninfectious.
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An outbreak of highly drug-resistant S. enterica Serotype Typhimurium which was resistant to all drugs tested was first identified in 2 young boys in 2004 in Minnesota and North Carolina who had been in contact with pet mice.
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Herbal Supplements to Treat Vasomotor Symptoms; Bisphosphonates to Treat LBD, After 5 Years?; FDA Actions
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The continuing emergence of a highly toxigenic strain of Clostridium difficile in the community has raised a troubling question for public health investigators: Is C. diff becoming a foodborne pathogen?
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A group of experts recently convened in San Francisco for a special discussion on the changing epidemiology of Clostridium difficile.
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Hospitalized patients with severe C. difficile-associated diarrhea were more likely to recover if they received vancomycin rather than the antibiotic metronidazole, which is typically the first-line therapy, an epidemiologist reports.
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The number of medical procedures performed in physician offices, clinics and other ambulatory care settings continues to increase, but these settings still operate with little regulatory oversight and there are few "drivers" to improve infection control and patient safety, experts warn.
