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Clinical Briefs

In this section: drug therapy for diabetes; timing surgical knee and hip replacement; and treating low back pain.

Brigatinib Tablets (Alunbrig)

Brigatinib is indicated for the treatment of patients with anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib.

Fludrocortisone for Orthostatic Hypotension Associated with Parkinson’s Disease

This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone.

Risk Factors for Hospital Readmissions Ending in Death or Transition to Hospice

In this retrospective cohort study, multiple factors were identified during initial hospitalization, including sepsis and shock, that were associated with a hospital readmission within 30 days resulting in death or transition to hospice.

Safe Treatment Recommendations for Benzodiazepine Dependence

There are clear, evidence-based treatment withdrawal regimens for benzodiazepine-dependent patients.

Infectious Disease Alert Updates

Colistin Resistance in Action; PK-tailored High-dose Colistin May Not Be Beneficial; ‘Dragon’s Blood’ Yields Possible Antibacterial

Oral Cholera Vaccine and Travelers

The new oral cholera vaccine is recommended for adults 18-64 years of age who are planning to travel to areas at risk.

Surviving Sepsis Campaign Guidelines Bundle: Studying How Improved Compliance Might Affect Outcomes

Improved compliance with the Surviving Sepsis Campaign guidelines bundle was associated with a non-statistically significant decrease in the in-hospital mortality of severe sepsis patients.

Ready for Dengue in the United States?

Dengue is increasingly recognized in the southern United States. When recently surveyed, however, clinicians in Texas seemed incompletely prepared to understand and manage patients with dengue.

Bambi Strikes Again — Encephalitis Due to the ‘Deer Tick Virus’ (Powassan Virus) May Be Increasing in Frequency

Powassan virus is transmitted by the same tick that carries the etiologic agent of Lyme disease and several other pathogens. The number of cases of encephalitis caused by this virus may be increasing in the endemic areas.