Infectious Disease General
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Infectious Disease Alert Updates
Occupational Mpox in Healthcare Workers; Homeless People at Risk for Mpox; PRIORIX Is Interchangeable with MMRII
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Outbreak of Botulism Due to Intragastric Botulinum Toxin Injection for Weight Loss
An outbreak of botulism after intragastric injection of botulinum toxin to cause weight loss has, to date, affected at least 87 patients.
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SER-109 Improves Quality of Life Compared to Placebo in Patients with Recurrent Clostridioides difficile Infection
A secondary analysis of a Phase III clinical trial found SER-109 improved health-related quality of life for patients with recurrent C. difficile infection compared to placebo through eight weeks.
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Shortening the Duration of Tuberculosis Treatment
In patients with rifampin-susceptible tuberculosis, a planned eight-week regimen of bedaquiline plus linezolid together with isoniazid, ethambutol, and pyrazinamide, combined with a careful follow-on strategy, was non-inferior to a standard six-month regimen.
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Infectious Disease Alert Updates
How to Assess CLABSI in Outpatient Infusion Therapy; Does Wearing Glasses Reduce the Risk of SARS-CoV-2 Infection?
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Form Follows Function — Structure-Based Vaccines Make Progress Against RSV
In older patients who are at risk for severe disease caused by respiratory syncytial virus (RSV), two new distinct vaccine candidates based on the stabilized prefusion F protein demonstrated efficacy and prevented RSV lower respiratory tract disease in patients older than age 60 years.
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Immortal Time Bias and Mortality Effects of 18F-FDG-PET/CT in Patients with Staphylococcus aureus Bacteremia
Staphylococcus aureus bacteremia is associated with high mortality and often is complicated by metastatic sites of infection that can be difficult to identify and control. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography has shown promise in some observational studies as an important diagnostic modality for detecting foci of infection and potentially guiding clinical management in ways that may lead to improved outcomes, including lower mortality. The validity of these findings has been questioned, however, due to the risk of significant bias.
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Highlights of Updated 2023 Pediatric Vaccination Schedules in the United States
In February, the annually updated immunization schedule for children in the United States was released by several professional organizations. Key updates involve the inclusion of the PCV-15 vaccine and COVID vaccines, as well as new comments about other vaccines.
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Dual Therapy Using Doxycycline and Azithromycin Is Superior to Monotherapy for Treating Severe Scrub Typhus
A multicenter, randomized, double-blind, controlled trial from India found dual therapy with intravenous doxycycline and azithromycin is more effective than either agent alone for treating severe scrub typhus.
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Golden State: Disseminated Gonococcal Infection
The diagnosis of disseminated gonococcal infection often is delayed, but the infection can most often be readily treated with ceftriaxone. Patients often lack urogenital symptoms.