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A 84-year-old retired professor was referred for second opinion regarding management of prostate cancer. He had been relatively healthy, with a history of hyperlipidemia and gout.
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Uric acid as a weak organic acid (pka 5.8) is poorly soluble at physiological pH.
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Myelodysplastic syndromes (MDS) usually occur in older adults and, as such, comorbid conditions are common. The investigators found that among 418 MDS patients, at least one comorbid condition existed in 93% at diagnosis. Comorbidity scores were generated using three common scoring systems: the HCT-CI, MDS-CI, and CCI. Worse survival was linked to higher CCI (p = 0.01) and MDS-CI (p = 0.02) but not HCT-CI. Higher CCI scores were associated with non-leukemic death and progression of red blood cell dependency, whereas higher comorbidity by HCT-CI and MDS-CI did not. Higher comorbid burden by CCI in MDS predicts for worse survival and non-leukemic death. Comorbidity data may help refine prognosis for MDS patients.
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Escitalopram for menopausal hot flashes, rifaximin for IBS without constipation, herpes zoster vaccination, antiepileptics drugs and fracture risk, and FDA Actions.
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The federal Agency for Healthcare Research and Quality's (AHRQ) $34 million initiative to prevent health care associated infections (HAIs) includes the following hospital-based projects.
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Already shown to reduce central line-associated blood stream infections (CLABSIs), a checklist protocol program has now shown to reduce mortality in ICU patients age 65 and over, researchers report.
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A catastrophic case of failed kidney transplants in two patients due to a multidrug resistant Escherichia coli infection in the donor underscores the critical role of communication and documentation between health care facilities, the Centers for Disease Control and Prevention emphasizes.
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The U.S. Occupational Safety and Health Administration may be becoming more cautious in its push for new regulations that include a standard on infectious diseases.
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Saying preventing health care associated infections (HAIs) is a national priority, the federal Agency for Healthcare Research and Quality (AHRQ) is putting considerable money where its mouth is: $34 million.
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As patients have moved, infections have moved with them. Accordingly, there is a surge of interest and research funding to implement and improve infection prevention beyond the hospital.
