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In a retrospective analysis of risk factors for the development of cerebral metastases in patients with known metastatic breast cancer, several factors including ER, HER-2, patient age, and site of first metastatic recurrence were found to be predicted. Using a cumulative incidence model employing competing-risk regression analysis, small initial tumor size, and the absence of metastatic disease at the time of diagnosis appeared to be independent risk factors.
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Preclinical data suggest bortezomib and rituximab have synergy for mantle cell lymphoma (MCL). The authors studied bortezomib, rituximab, and dexamethasone in relapsed and refractory MCL using 1.3 mg/m2 of bortezomib on days 1, 4, 8, and 11 with rituximab on day 1 and 40 mg of dexamethasone on days 1-4.
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A 57-year-old, postmenopausal African American schoolteacher was found by annual screening mammogram to have a suspicious irregularity. Follow-up ultrasound did not reveal cystic disease so a repeat "spot" mammogram-assisted biopsy was obtained and a grade 1 invasive ductal carcinoma with tubular elements was found.
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A few years ago, vitamin E was deemed to be an extremely important nutrient required to maintain health, prevent or delay several disorders, and prolong life. However, many clinical trials involving intervention with supplemental administration of vitamin E failed to establish or confirm these benefits. A similar prominence is being afforded at present to vitamin D because of relationships being documented between vitamin D deficiency and multiple outcomes, including several disorders and mortality.
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Drowning is defined as asphyxia or suffocation from submersion/immersion in a liquid medium.
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Although most critically ill patients require only short periods of respiratory support, a minority require prolonged mechanical ventilation (PMV).
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