Browse Dementia/Alzheimer Disease Articles by Topic

Repeated Head Impacts Are Associated with Tau Astrogliopathy

This study demonstrates that both traumatic brain injury and participation in contact sports are independently associated with increased tau astrogliopathy, particularly thorn-shaped astrocytes, even when cases of chronic traumatic encephalopathy neuropathologic change are excluded.

Cycling into Cognitive Health: Lessons from the U.K. Biobank

In this large prospective study, active travel (especially cycling) was associated with lower dementia incidence both overall and for specific types of dementia as well as greater hippocampal volume.

MIND Matters: Diet, Exercise, and Engagement in Cognitive Health

This multicenter, randomized clinical trial showed that a highly structured, multidomain lifestyle intervention modestly but significantly was associated with improved global cognitive function throughout two years in at-risk older adults, compared to a lower-intensity, self-guided program.

Gabapentin and the Risk of Dementia in Adults with Chronic Pain

In a retrospective cohort study, gabapentin prescription in adults with chronic low back pain was associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults.

Semaglutide May Reduce Dementia Risk

In a large nationwide population-based study, semaglutide significantly reduced Alzheimer’s disease-related dementia risk compared to insulin, metformin, and older glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes.

24-Hour Activity Rhythms and Amyloid-β Deposition in the Brain

This study of dementia-free adults found that greater variability of the 24-hour activity rhythm (greater during the daytime as well as during sleep time) with fragmentation of sleep predicted increased deposition of amyloid-β (Aβ), especially in apolipoprotein E 4 (APOE4) carriers.

Epilepsy in Frontotemporal Dementia

This Finnish case-control study explores the relationship between frontotemporal dementia (FTD) and epilepsy, revealing that individuals with FTD have a higher prevalence of epilepsy compared to those with Alzheimer’s disease (AD) and healthy controls. The findings suggest that epilepsy may precede FTD diagnosis and is more common in FTD than previously recognized, highlighting the need for broader research and clinical awareness of this comorbidity.

TIA Is Associated with Accelerated Cognitive Decline

The study investigators looked at data from a prospective study of 30,239 Black and white community-dwelling persons aged 45 years or older with cognitive evaluations over the phone every other year until 2022. The researchers documented patients who had transient ischemic attack (TIA) or stroke, and demonstrated that persons who had TIA had a cognitive decline trajectory similar to those patients who had a definite diagnosis of stroke.

Can Anti-Amyloid Antibody Treatment Delay the Clinical Onset of Alzheimer’s Disease?

In this open-label extension of the dominantly inherited Alzheimer’s disease gantenerumab trial (DIAN-TU), long-term continuous amyloid clearance over eight or more years in asymptomatic carriers of autosomal dominant Alzheimer’s mutations showed potential to delay symptom onset and slow progression. Shorter duration or partial clearance did not yield measurable clinical benefit, suggesting that only sustained, near-complete amyloid removal may have disease-modifying effects.

Long-Term NSAID Use May Lower Dementia Risk

In a prospective population-based study of nonsteroidal anti-inflammatory drugs, long-term use was associated with a reduced risk for dementia compared with short- and intermediate-term use.