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  • Improving the Use of Prophylactic Antibiotics

    Diluigi and colleagues in Rhode Island compared the outcomes of 400 patients undergoing hysterectomy with 686 hysterectomy cases performed prior to the institution of a policy for prophylactic antibiotics. Abdominal, vaginal, and laparoscopic cases were included, with the primary aspects being rates and timing of preoperative antibiotic administration as well as postoperative febrile morbidity.
  • VBAC Revisited

    In some hospitals Vaginal Birth After Cesarean (VBAC) has been eliminated as an option for patients having had previous Cesarean sections. Although the major reason stated for this position has been risk of uterine rupture, there is more to this stance which involves potential liability and the inconvenience to providers of having to be immediately available for the duration of these patients labors.
  • Effects of a Low-Glycemic Load Diet on Resting Energy Expenditure and Heart Disease Risk Factors During Weight Loss

    The effect of caloric restriction upon metabolism was gated by whether sugars or fats were preferentially restricted. A low-glycemic load diet (glucose restriction) yielded more favorable biochemical profiles than restricting fats.
  • Immunotherapy for Consolidation Treatment of Ovarian Cancer — Is This the One?

    Consolidation therapy with oregovomab did not significantly improve TTR overall. A set of confirmatory phase III studies has been initiated to determine whether the SFLT population derives benefit from oregovomab treatment.
  • The WHI-Wayne State Fracas

    Womens Health Initiative (WHI) investigators from Wayne State University performed an analysis using the WHI database and presented the results at the 2004 annual meeting of the American Society of Reproductive Medicine (ASRM). Two months later, the presentation on the effects of oral contraception on cardiovascular disease drew a critical response from the director of the WHI, Barbara Alving, MD, who is also the acting director of the National Heart, Lung, and Blood Institute.
  • Pharmacology Watch: Statins and the Incidence of Rhabdomyolysis

    A Crackdown on Importation of Drugs; FDA Actions.
  • Clinical Briefs in Primary Care supplement

  • Clinical Briefs in Primary Care

    Antioxidant Supplements for Prevention of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis; Two 8-month Regimens of Chemotherapy for Treatment of Newly Diagnosed Pulmonary Tuberculosis; Self-Measured Home Blood Pressure in Predicting Ambulatory Hypertension; Thyroid Status, Disability and Cognitive Function, and Survival in Old Age; Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women.
  • Abnormal Bleeding Risk with SSRIs

    Increased hospitalizations for abnormal bleeding were found in new users of selective serotonin reuptake inhibitor (SSRI) antidepressants, with more risk associated with SSRIs containing greater degrees of serotonin reuptake inhibition.
  • Barrett’s Esophagus Progression and Proton Pump Inhibitors

    Examining data from a 20-year time period, correlations were sought between antisecretory drug therapy and cumulative incidence of dysplasia. Incidence of dysplasia was significantly lower in patients who had received proton pump inhibitor therapy vs no therapy or H2-receptor antagonists.