Clinical
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Infectious Disease Alert Updates
California Firefighters at Risk for Cocci; Hyperglycemia and Diabetes with INSTIs; Positive Sputum in Extra-Pulmonary Tuberculosis
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Comparison of Postoperative Antibiotic Regimens for Complex Appendicitis: Is Two Days as Good as Five Days?
In a pragmatic, open-label, randomized trial conducted at 15 hospitals in the Netherlands, two days of postoperative intravenous antibiotics for complex appendicitis was found to be noninferior to five days in terms of infectious complications and mortality within 90 days.
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Does COVID Vaccination Prevent Car Crashes?
In a large Canadian study, lack of COVID vaccination was associated with an increased incidence of being injured in a car crash.
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Fungal Meningitis After Epidural Injections — Again
An outbreak in Mexico of meningitis due to Fusarium solani has affected at least 79 patients who had received epidural injections; at least 35 have died.
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Nationwide Outbreak of Extensively Drug-Resistant Pseudomonas aeruginosa Infections from Contaminated Eye Drops
An outbreak of extensively drug-resistant Pseudomonas aeruginosa infection has been traced to use of contaminated artificial tears.
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A Rapid Molecular Test Improves Time to Appropriate Therapy and Mortality in Patients with CRE Bacteremia
A multicenter observational study of patients with carbapenem-resistant Enterobacterales bacteremia found that time to receipt of active antibiotic therapy and mortality were improved in those whose blood cultures underwent rapid molecular testing for the Klebsiella pneumoniae carbapenemase gene. The mortality rate was 10% with ceftazidime-avibactam compared to 31% with polymyxin monotherapy.
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Asymptomatic with Inverted T Waves
The ECG in the figure is from a healthy young adult without symptoms. Clinicians recorded this tracing as part of the patient’s employment physical exam. Is the T wave inversion likely to be a normal variant?
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Daprodustat (Jesduvroq)
Daprodustat can be prescribed to treat anemia caused by chronic kidney disease in adults who have been receiving dialysis for at least four months.
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Does Surviving an ECMO Stay Put Patients at Greater Risk for Mental Health Problems?
Survivors of extracorporeal membrane oxygenation (ECMO) demonstrated a modest increase in risk of new mental health diagnoses after discharge vs. ICU survivors who do not undergo ECMO.
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Can a Blood-Based Test Serve as a Biomarker for Parkinson’s Disease?
The authors of this proof-of-concept study proposed that a noninvasive assay detecting pathology-associated α-synuclein extracted from blood may reveal a reliable biomarker for Parkinson’s disease.