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Letrozole for Postmenopausal Women with Breast Cancer; Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart Function?; Can Tamoxifen Increase Your Height?; A Dramatic Increase of Clostridium difficile; FDA Actions
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There have been no new agents approved to treat gout for over 20 years. Because the plasma becomes supersaturated at a uric acid level of 6.0 mg/dL, it is felt that persons with a diathesis for tissue deposition of urate (gouty arthritis, tophi, or both) will optimize benefit by maintaining serum uric acid (SUA) below this level.
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Patient 1: A healthy 18-year-old woman underwent medical abortion at 47 days gestation and 4 days later was seen in an emergency ward with abdominal cramping. She was afebrile and there was no tenderness on physical examination.
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In the December Green Journal there was an excellent review by Ken Moise on the current status of umbilical cord blood stem cells. Since this is a topic patients frequently ask about, this month I will depart from the usual alert format to abstract this informative article.
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The standard approach to adjuvant therapy in women with advanced ovarian cancer is intravenous platinum-based chemotherapy, usually in combination with a taxane. Since the disease is largely characterized by a disseminated intraperitoneal spread pattern, investigators have been interested as whether the disease may respond to therapy administered in the same route.
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In a clinical trial conducted in Mexico City, 162 women with systemic lupus erythematosus were randomized to treatment with 1 of 3 contraceptive methods: estrogen-progestin oral contraceptives, oral progestin-only, or a copper IUD. Disease activity remained equally mild and stable over 1 year in all 3 groups.
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Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart
Function?; A Dramatic Increase of Clostridium difficile; FDA Actions
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The first article reports the results of an industry-sponsored clinical trial comparing TDF/ABC/3TC vs EFV/ABC/3TC in treatment-naïve patients. Three hundred forty patients were randomized. Baseline characteristics, including CD4 count and HIV RNA level were similar between the arms.
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Since the fda approval of moxifloxacin in December 1991 for the treatment of community-acquired pneumonia, sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin/skin structure infections, its indications for use has been expanded to include the treatment of complicated skin/skin structure infections and complicated intra-abdominal infections.
