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Preventing SARS-CoV-2 Infection with an Allergy Nasal Spray
Use of the antihistamine azelastine nasal spray was effective in preventing SARS-CoV-2 infection in young, healthy, vaccinated outpatients.
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Patients Aged 6 Months and Older with Egg Allergy Should Receive Flu Vaccine
The Advisory Committee on Immunization Practices (ACIP) provided updated guidance for the 2025-2026 influenza season. After reviewing data on egg-based influenza vaccines, ACIP reinforced that individuals with egg allergies are not at increased risk of severe allergic reactions and outlined precaution and contraindication considerations in vaccine administration for this population.
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The Health and Economic Burden of Long COVID in the United States
Researchers using a computational simulation model found that the current health and economic burden of long COVID already exceeds the cost of several chronic diseases and will continue to grow as COVID-19 cases increase.
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Beta-Blocker Interruption Post-MI
An analysis of the secondary outcomes in the French multicentered study of beta-blocker withdrawal in patients with uncomplicated myocardial infarction after one year led to increases in heart rate and blood pressure with potentially deleterious outcomes, especially in patients with a history of hypertension.
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Statins for Abdominal Aortic Aneurysms
An analysis of two large, abdominal aortic aneurysm (AAA) screening populations from Denmark has shown that high-dose statin therapy reduces the rate of AAA growth, the need for repair, and adverse outcomes, such as rupture and death.
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Community-Acquired Pneumonia Guidelines: Updates and Disputes
An update of elements of community-acquired pneumonia guidelines has been published. Of note is that these were not endorsed by the Infectious Diseases Society of America because of disagreement over recommendations for empiric antibiotic administration to some patient subsets with positive tests for respiratory viral infection.
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The Walk ’n Watch Trial: Stroke Recovery Through High-Intensity Walking
An intensive real-life walking protocol, started as soon as possible after acute stroke, resulted in improved overall walking endurance, mobility, balance, and quality of life
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Plasma Exchange for Relapses in MOGAD
In this multicenter, international study of a cohort of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), the authors examined the effectiveness of plasma exchange for acute relapses and reported favorable disability outcomes but found that advanced age and delayed initiation of the treatment reduced its benefit.
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Potential Benefit of Glyburide in Moderate-Volume Acute Ischemic Stroke
An exploratory analysis of the CHARM trial suggests intravenous glyburide may improve outcomes in large hemispheric stroke patients with infarct volumes < 125 mL, particularly alongside thrombectomy, reducing edema, mortality, and the need for decompressive surgery, and highlighting a potential neuroprotective role.
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Repeated Head Impacts Are Associated with Tau Astrogliopathy
This study demonstrates that both traumatic brain injury and participation in contact sports are independently associated with increased tau astrogliopathy, particularly thorn-shaped astrocytes, even when cases of chronic traumatic encephalopathy neuropathologic change are excluded.