Clinical
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Human Paraechovirus Encephalitis in Children
Human paraechovirus (HPeV) causes encephalitis and is more common in very young or premature female infants. Affected children commonly present with seizures. Diffusion restriction on MRI in the absence of CSF pleocytosis is seen. Neurodevelopmental sequelae are common after long-term follow up.
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Zika!
Zika virus infection has prompted international emergency responses due to its rapid spread in the Americas and its potential to alter brain development in pre-born children. Even as research progresses, prevention of infection depends on avoiding bites from Aedes mosquitoes.
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Gender Equality in Primary Prevention ICD Benefit
In a propensity-matched study, women who received a primary prevention implantable cardioverter defibrillator had a significant survival advantage, which was similar to that observed among men.
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Permanent Pacemaker After TAVR: A Modifiable Risk?
A study of the latest-generation balloon-expandable valves demonstrates a higher rate of new conduction abnormalities and pacemaker implants than previous models.
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One Procedure or Two? Study Examines Staging for Multi-vessel PCI in NSTEMI
In patients with non-ST elevation myocardial infarction and multi-vessel disease, single-stage percutaneous coronary intervention during the initial procedure is superior to multiple procedures in terms of major adverse cardiovascular and cerebrovascular events and minor bleeding at 1 year.
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Nitrate Therapy Shows Possible Harm in Heart Failure with Preserved Ejection Fraction
In heart failure with preserved ejection fraction, the use of isosorbide mononitrate was associated with a nonsignificant decrease in physical activity level, and no improvement in symptoms or quality of life.
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The Portal of Bacterial Entry in Infective Endocarditis
ABSTRACT & COMMENTARY: A comprehensive, systematic search for the portal of bacterial entry in infective endocarditis is frequently successful.
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By Using In Vitro Fertilization, Pregnancy Rates Can Approach Those in Fertile Women
Cumulative live-birth rates were more than 65% after the sixth cycle of in vitro fertilization.
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Use of CNMs and Hospitalists
A study assessing the effects of instituting a model of certified nurse midwife with MD laborist backup on a private patient population showed a decrease in cesarean section rate and an increase in vaginal birth after cesarean delivery rate without any change in combined neonatal outcome.
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Fluconazole Use During Pregnancy
In this large cohort study from Denmark, use of oral fluconazole during pregnancy was associated with a slightly increased risk of spontaneous abortion and no increased risk of stillbirth.