Clinical
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Longer Course Therapy for Lyme Disease Is Not Beneficial
A randomized, placebo-controlled clinical trial from the Netherlands found that longer-term antibiotic therapy for Lyme disease did not improve health-related quality of life compared to a standard course of treatment.
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Alexander Technique, Acupuncture, or Routine Care for Chronic Neck Pain
Alexander Technique lessons or acupuncture sessions for people with chronic neck pain led to greater decreases in neck pain and disability and a more significant increase in self-efficacy than normal care at 12 months.
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Individualized Homeopathy for Moderate to Severe Depression in Menopausal Women
A higher risk of depressive symptoms has been observed in the menopausal transition period. Antidepressant medications are often recommended; however, many meta-analyses have only shown modest benefit of such medications over placebo. This study compares individual homeopathic treatment vs. placebo and the antidepressant medication fluoxetine vs. placebo for the treatment of moderate to severe depression in peri- and postmenopausal women.
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Fitness and Cognition in the Elderly
ABSTRACT & COMMENTARY: Peak levels of cardiorespiratory fitness are positively correlated with enhanced cognitive function among older adults.
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Low Back Pain Best Prevented with Exercise and Education
In a meta-analysis of studies on preventing low back pain, researchers found a combination of exercise and education were the most likely interventions to prevent recurrence of this potentially debilitating condition.
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Can Chemotherapy Damage Heart Valves?
Long-term lymphoma survivors were noted to experience valvular regurgitation out of proportion to reductions in left ventricular function and degenerative valve stenosis. The most evidence appeared in those who received radiation therapy in addition to chemotherapy.
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Postoperative Atrial Fibrillation Management — You Can’t Go Wrong
Rate control and rhythm control strategies for cardiac surgery patients with postoperative atrial fibrillation lead to similar hospital durations, similar complication rates, and similar very low rates of atrial fibrillation at 60-day follow-up.
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Can CABG Really Improve Left Ventricular Function?
In implantable cardioverter defibrillator candidates with an ejection fraction < 35% who underwent coronary artery bypass graft surgery, mean ejection fraction improved significantly, especially in those with baseline ejection fraction between 25-35%, obviating the need for an implantable cardioverter defibrillator in 58%.
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CABG Improves Long-term Survival in Severe Left Ventricular Dysfunction
In patients with coronary artery disease, heart failure, and left ventricular ejection fraction < 35%, coronary artery bypass grafting plus medical therapy was associated with improved survival compared to medical therapy alone.
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TAVR in Intermediate-risk Patients: How Low Can We Go?
Transcatheter and surgical aortic valve replacement in an intermediate-risk population have similar rates of death and disabling stroke at two years.