Clinical
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Noninvasive Ventilation Delivered Via Helmet May Decrease Intubation Rates
SYNOPSIS: In this single-center, randomized, clinical trial, among patients suffering from acute respiratory distress syndrome, the use of helmet noninvasive ventilation was associated with a reduction in intubation rates, ICU length of stay, and hospital and 90-day mortality.
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Influence of Sacubitril/Valsartan on 30-day Readmission After Heart Failure
SYNOPSIS: Compared with enalapril, treatment with sacubitril/valsartan is more effective in reducing 30-day readmissions for any cause following discharge from congestive heart failure hospitalization.
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Growing Threat of Pyelonephritis Caused by Antibiotic-resistant Escherichia coli
SYNOPSIS: In patients with acute pyelonephritis due Escherichia coli presenting to one of 10 emergency departments, the prevalence of fluoroquinolone resistance ranged from 6.3% to 19.9%, and the prevalence of extended-spectrum beta-lactamase production was 2.6% to 12.2%. Of those patients with resistant organisms, more than 50% received inactive empiric antibiotics.
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Safely Centralized Telemetry Off-site in a Multi-hospital System
SYNOPSIS: The hospitals in this study outsourced their cardiac telemetry to an off-site central monitoring center without an increase in adverse events.
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FDA Actions
In this section: FDA removes black box warning from Chantix; approves first biosimilar to Humira; issues warning about hepatitis C drug; and green lights first drug to treat common childhood form of muscular dystrophy.
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Experts Withdraw Support for Codeine in Children
After years of debate, the American Academy of Pediatrics has issued a Clinical Report recommending against the use of codeine for cough or pain in children, regardless of age.
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New Erectile Dysfunction Data Counter Previous Studies
This study will be a relief for men who take 5-alpha reductase inhibitors, since previous studies suggested erectile dysfunction may be a significant problem with these drugs.
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New Study Compares Leading Atrial Fibrillation Treatments
The authors concluded that rivaroxaban use for atrial fibrillation was associated with significantly higher rates of intracranial hemorrhage and major extracranial bleeding.
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The Importance of Low Uric Acid in Gout Patients
Consistent abolition of acute flares has been confirmed only when uric acid levels < 6.0 mg/dL are maintained over the long term.
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Does Technology Accelerate Weight Loss?
Trial participants randomized to add-on gadgetry actually experienced less weight loss than those who simply received traditional diet and exercise advice.