Browse Clinical Articles by Topic

Fludrocortisone for Orthostatic Hypotension Associated With Parkinson’s Disease

This double-center, double-blind, randomized, controlled trial compared the efficacy of pyridostigmine bromide vs. fludrocortisone and demonstrated that pyridostigmine bromide was not as effective as fludrocortisone. The authors also provided evidence for the efficacy of fludrocortisone in treating neurogenic orthostatic hypotension.

Rituximab for Myasthenia Gravis

In uncontrolled, observational case series, rituximab treatment for myasthenia gravis appears to be effective and safe, but more studies are needed for confirmation.

Blood-brain Barrier Breakdown in RCVS

In this single-center, prospective trial, patients with reversible cerebral vasoconstriction were found to have evidence of blood-brain barrier breakdown on MRI.

Beetroot Juice and Aerobic Endurance and Blood Pressure

Researchers found that drinking beetroot juice daily improves submaximal aerobic endurance in patients with cardiac failure and preserved ejection fraction.

Low Back Pain: Evidence for Nonpharmacologic Therapies

Developed for use in the new American College of Physicians guidelines, the authors reviewed evidence regarding non-pharmacologic interventions in treatment of low back pain.

Insomnia Disorder: Evidence for Psychological and Behavioral Interventions

Cognitive behavioral therapy for insomnia (CBT-I) is an effective intervention for moderate to severe insomnia disorder and should be considered as an initial treatment.

Tai Chi for Knee Osteoarthritis

Tai chi is as effective as a standard course of physical therapy in the treatment of pain of osteoarthritis of the knee.

Infectious Disease Alert Updates

Sepsis Survival Affected by Drug Shortage;

A Rare Cause of Eosinophilic Meningoencephalitis;

Look, Ma! I Hooked My Thumb

Guillain-Barré Syndrome and Hepatitis E

Hepatitis E is the most common form of viral hepatitis worldwide and often is asymptomatic. But it is commonly associated with Guillain-Barré syndrome and Guillain-Barré variants.

Beta-lactam Antibiotics May Be Useful in MRSA Infection

Using several in vitro assays and animal models, it was shown that oxacillin-treated methicillin-resistant Staphylococcus aureus strains are attenuated in virulence. The effect is mediated by repression of accessory gene regulatory quorum-sensing system and altered cell wall architecture.